Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 11/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27860912 | 0.92 | CCR1 (0.46) | CXCR4PRMT5WDR77CCR1CCR5 | |
| SCHEMBL18406191 | 0.83 | LMNA (0.51) | PRMT5WDR77 | |
| SCHEMBL1329027 | 0.78 | HSD11B1 (0.55) | PRMT5WDR77GRM5SCD5RIPK1 | |
| SCHEMBL18394381 | 0.78 | PROKR1 (0.45) | PRMT5WDR77GRM5SCD5RIPK1 | |
| SCHEMBL30444775 | 0.75 | GRM5 (0.42) | PRMT5WDR77GRM5SCD5 | |
| SCHEMBL29785721 | 0.74 | PRMT5 (0.56) | PRMT5WDR77GRM5SCD5RIPK1 | |
| SCHEMBL3361751 | 0.74 | PRMT5 (0.56) | PRMT5WDR77GRM5SCD5RIPK1 | |
| SCHEMBL17142309 | 0.73 | CCNC (0.41) | HCRTR2GRM5RIPK1TRPV1 | |
| SCHEMBL17142323 | 0.73 | RIPK1 (0.55) | PRMT5WDR77SCD5RIPK1 | |
| SCHEMBL17142336 | 0.73 | KMO (0.46) | GRM5SCD5RIPK1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126545-A2 | DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF | The Trustees of Princeton University (US) | 2017-02-08 | — | — | EP | disclosed |
| US-20170022185-A1 | DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2017-01-26 | — | — | US | disclosed |
| WO-2015153381-A2 | DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022185-A1 | DECARBOXYLATIVE CROSS-COUPLING AND APPLICATIONS THEREOF | PPOX, DDO, DDC | CXCR4 3188/4885PRMT5 1525/4885WDR77 2675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.