Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12460028 | 0.91 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1GAATDP1RAB9A | |
| SCHEMBL3948068 | 0.87 | ALDH1A1 (0.54) | L3MBTL1ALDH1A1TDP1RAB9ASMN1; SMN2 | |
| SCHEMBL27675955 | 0.80 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1GAATDP1RAB9A | |
| SCHEMBL5487638 | 0.80 | CYP1A2 (0.46) | L3MBTL1TDP1CYP1A2TSHR | |
| SCHEMBL13150211 | 0.78 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL3718145 | 0.78 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1GAATDP1RAB9A | |
| SCHEMBL7524992 | 0.77 | MAPK1 (0.47) | L3MBTL1ALDH1A1GAATDP1RAB9A | |
| SCHEMBL3332335 | 0.76 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL27583164 | 0.76 | LMNA (0.42) | L3MBTL1ALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL8009396 | 0.76 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1GAATDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685112-B1 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES AS VR1 ANTAGONISTS | BAYER SCHERING PHARMA AG (DE) | 2011-07-20 | — | — | EP | disclosed |
| US-20100137361-A1 | Tetrahydro-Quinolinylurea Derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-03 | — | — | US | disclosed |
| US-20100137361-A1 | Tetrahydro-Quinolinylurea Derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-03 | — | — | US | disclosed |
| US-20100137361-A1 | Tetrahydro-Quinolinylurea Derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-03 | — | — | US | disclosed |
| US-7683076-B2 | Tetrahydro-quinolinylurea derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-23 | — | — | US | disclosed |
| US-7683076-B2 | Tetrahydro-quinolinylurea derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-23 | — | — | US | disclosed |
| US-7683076-B2 | Tetrahydro-quinolinylurea derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-23 | — | — | US | disclosed |
| US-20070213363-A1 | Tetrahydro-Quinolinylurea Derivatives | BAYER HEALTHCARE AG (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213363-A1 | Tetrahydro-Quinolinylurea Derivatives | BAYER HEALTHCARE AG (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213363-A1 | Tetrahydro-Quinolinylurea Derivatives | BAYER HEALTHCARE AG (DE) | 2007-09-13 | — | — | US | disclosed |
| EP-1685112-A2 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES | Bayer HealthCare AG (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005044802-A2 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES AS VRL ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213363-A1 | Tetrahydro-Quinolinylurea Derivatives | NMUR1, OPRL1, NQO2 | L3MBTL1 2394/4885ALDH1A1 931/4885GAA 2347/4885 |
| US-20100137361-A1 | Tetrahydro-Quinolinylurea Derivatives | NMUR1, OPRL1, HVCN1 | L3MBTL1 2042/4885ALDH1A1 644/4885GAA 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.