Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156295 | 0.74 | DHODH (0.39) | DHODH | |
| SCHEMBL3263525 | 0.71 | RAB9A (0.43) | MAPTHPGDNPSR1 | |
| SCHEMBL17156093 | 0.66 | DHODH (0.43) | ALKBH1TSHRKDM4EALDH1A1MEN1 | |
| SCHEMBL3259619 | 0.64 | RAB9A (0.47) | KDM4EALDH1A1MEN1MAPTHPGD | |
| SCHEMBL12676870 | 0.62 | L3MBTL1 (0.49) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL17156381 | 0.61 | ADORA3 (0.42) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL17156371 | 0.61 | DHODH (0.57) | ALKBH1TSHRKDM4EALDH1A1MEN1 | |
| SCHEMBL17156327 | 0.61 | ADORA3 (0.48) | TSHRKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL17680558 | 0.60 | ADCY10 (0.45) | TSHRALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL9009276 | 0.60 | CYP11B2 (0.45) | TSHRKDM4EALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |