Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720325 | 0.77 | ADORA3 (0.42) | KDM4EALDH1A1ADORA3ADORA2AADORA2B | |
| SCHEMBL2686641 | 0.77 | ADORA2B (0.49) | STIM1ORAI1CCNT1ADORA3ADORA2A | |
| SCHEMBL1720586 | 0.72 | EIF4E (0.48) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL1720825 | 0.72 | STIM1 (0.43) | STIM1ORAI1CCNT1CDK9KDM4E | |
| SCHEMBL1720377 | 0.70 | CCNT1 (0.41) | STIM1ORAI1CCNT1 | |
| SCHEMBL2687202 | 0.68 | ADORA2B (0.51) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL21667384 | 0.67 | GPR84 (0.45) | KDM1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23860278 | 0.66 | TLR7 (0.34) | KDM1ACCNT1CDK9KDM4EALDH1A1 | |
| SCHEMBL25173964 | 0.65 | KDM4E (0.42) | KDM1ACCNT1CDK9KDM4EALDH1A1 | |
| SCHEMBL2686174 | 0.65 | ADORA2B (0.66) | ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | disclosed |