Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 16/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720580 | 0.90 | SCD (0.38) | CCNT1 | |
| SCHEMBL1727143 | 0.78 | ADORA2B (0.41) | CCNT1GAA | |
| SCHEMBL2686641 | 0.75 | ADORA2B (0.49) | STIM1ORAI1CCNT1 | |
| SCHEMBL1720374 | 0.72 | STIM1 (0.43) | STIM1ORAI1CCNT1KDM4EALDH1A1 | |
| SCHEMBL2687202 | 0.66 | ADORA2B (0.51) | — | |
| SCHEMBL1872803 | 0.64 | ADORA1 (0.59) | CCNT1GAACDK9 | |
| SCHEMBL1720325 | 0.63 | ADORA3 (0.42) | KDM4EALDH1A1 | |
| SCHEMBL21667384 | 0.62 | GPR84 (0.45) | KDM4EALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL2686174 | 0.62 | ADORA2B (0.66) | — | |
| SCHEMBL14226010 | 0.60 | STIM1 (1.00) | STIM1ORAI1CCNT1CDK9NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | claimed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | claimed |
| EP-3727391-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER | Impetis Biosciences Ltd. (IN) | 2020-10-28 | — | — | EP | disclosed |
| EP-2405917-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | Advinus Therapeutics Private Limited (IN) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103547-A2 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2010-09-16 | — | — | WO | disclosed |