SCHEMBL17211607

SCHEMBL17211607

C=C(C)C(=O)OCCOC(=O)c1c(I)c(NC(C)=O)c(I)c(NC(C)=O)c1I

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.46
THRB P10828 1/20 0.41
TSHR P16473 4/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
POLB P06746 2/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
KMT2A Q03164 1/20 0.33
APEX1 P27695 1/20 0.33
HTT P42858 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ALDH1A1 P00352 3/20 0.32
HPGD P15428 1/20 0.31
RECQL P46063 1/20 0.31
PKM P14618 1/20 0.31
MAPK1 P28482 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22168536 0.92 THRB (0.40) LMNATHRBTSHRSMN1; SMN2CA1
SCHEMBL23230272 0.90 LMNA (0.38) LMNATHRBTSHRSMN1; SMN2CA1
SCHEMBL20204440 0.89 THRB (0.40) LMNATHRBTSHRSMN1; SMN2CA1
SCHEMBL9852571 0.82 LMNA (0.51) LMNATSHRSMN1; SMN2POLBMEN1
SCHEMBL7767924 0.82 LMNA (0.40) LMNATSHRSMN1; SMN2
SCHEMBL23230276 0.82 THRB (0.42) LMNATHRBTSHRSMN1; SMN2MEN1
SCHEMBL20629507 0.81 THRB (0.42) THRBTSHRCA1CA2POLB
SCHEMBL22698340 0.81 THRB (0.46) LMNATHRBTSHRSMN1; SMN2POLB
SCHEMBL12845801 0.79 HPGD (0.51) LMNATSHRSMN1; SMN2NPC1RAB9A
SCHEMBL26309205 0.79 LMNA (0.39) LMNASMN1; SMN2POLBMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11857694-B2 Particles MICROVENTION, INC. (US) 2024-01-02 US disclosed
US-11857694-B2 Particles MICROVENTION, INC. (US) 2024-01-02 US disclosed
US-20220176012-A1 PARTICLES MICROVENTION, INC. 2022-06-09 US disclosed
US-11285240-B2 Particles MICROVENTION, INC. (US) 2022-03-29 US disclosed
US-10946100-B2 Polymers including active agents MICROVENTION, INC. (US) 2021-03-16 US disclosed
US-20200397942-A1 PARTICLES MICROVENTION, INC. 2020-12-24 US disclosed
US-20200368171-A1 PARTICLES MICROVENTION, INC. 2020-11-26 US disclosed
US-10792390-B2 Particles MICROVENTION, INC. (US) 2020-10-06 US disclosed
US-20200209747-A1 POSITIVE RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2020-07-02 US disclosed
US-20200121824-A1 PARTICLES MICROVENTION, INC. 2020-04-23 US disclosed
US-20180147317-A1 PARTICLES MICROVENTION, INC. 2018-05-31 US disclosed
US-20180147317-A1 PARTICLES MICROVENTION, INC. 2018-05-31 US disclosed
US-9907880-B2 Particles MICROVENTION, INC. 2018-03-06 US disclosed
US-9907880-B2 Particles MICROVENTION, INC. 2018-03-06 US disclosed
WO-2016154592-A1 EMBIOLIC PARTICLES MICROVENTION, INC. (US) 2016-09-29 WO disclosed
US-20160279282-A1 PARTICLES MICROVENTION, INC. 2016-09-29 US disclosed
US-20160279282-A1 PARTICLES MICROVENTION, INC. 2016-09-29 US disclosed
WO-2015167752-A1 POLYMERS INCLUDING ACTIVE AGENTS MICROVENTION, INC. (US) 2015-11-05 WO disclosed
US-20150306227-A1 POLYMERS INCLUDING ACTIVE AGENTS MICROVENTION, INC. 2015-10-29 US disclosed
US-20150306227-A1 POLYMERS INCLUDING ACTIVE AGENTS MICROVENTION, INC. 2015-10-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10946100-B2 Polymers including active agents MFAP1, VCL, ACTB LMNA 199/4885THRB 4671/4885TSHR 4588/4885
US-20200209747-A1 POSITIVE RESIST COMPOSITION AND PATTERNING PROCESS INSR, INSRR, ZFR LMNA 1042/4885THRB 475/4885TSHR 106/4885
US-20150306227-A1 POLYMERS INCLUDING ACTIVE AGENTS MFAP1, VCL, ACTB LMNA 199/4885THRB 4671/4885TSHR 4588/4885
US-20200368171-A1 PARTICLES SELP, CD47, THPO LMNA 1787/4885THRB 4255/4885TSHR 2282/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.