Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.52 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359102 | 0.77 | TLR8 (0.57) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL29454362 | 0.77 | TLR8 (0.57) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL27880744 | 0.77 | ALDH1A1 (0.56) | ALDH1A1HPGDMAPTGLAACHE | |
| Hydrochloric Acid SCHEMBL27365120 | 0.76 | TLR8 (0.55) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL10827474 | 0.75 | ALDH1A1 (0.75) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL2200581 | 0.74 | TLR8 (0.53) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL846680 | 0.74 | KMT2A (0.55) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL1133368 | 0.74 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL8788171 | 0.74 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTGLAACHE | |
| SCHEMBL358560 | 0.74 | TDP1 (0.59) | ALDH1A1HPGDMAPTGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406228-B1 | Substituted 3-amino-2-mercaptochinolins as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-09-18 | — | — | EP | claimed |
| US-8207342-B2 | Substituted 3-amino-2-mercaptoquinolines as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2012-06-26 | — | — | US | claimed |
| EP-2406228-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | claimed |
| WO-2010102779-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | claimed |
| US-20100234421-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2010-09-16 | — | — | US | claimed |
| EP-1909142-B1 | PHOTOSENSITIVE RESIN COMPOSITION AND ADHESION ENHANCER | TORAY INDUSTRIES (JP) | 2015-06-24 | — | — | EP | disclosed |
| EP-2406228-B1 | Substituted 3-amino-2-mercaptochinolins as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-09-18 | — | — | EP | disclosed |
| EP-2406228-B1 | Substituted 3-amino-2-mercaptochinolins as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-09-18 | — | — | EP | disclosed |
| US-8207342-B2 | Substituted 3-amino-2-mercaptoquinolines as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| US-8207342-B2 | Substituted 3-amino-2-mercaptoquinolines as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| US-8207342-B2 | Substituted 3-amino-2-mercaptoquinolines as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2012-06-26 | — | — | US | disclosed |
| CN-102341374-A | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | GRUENENTHAL GMBH | 2012-02-01 | — | — | CN | disclosed |
| US-20030065006-A1 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY | 2003-04-03 | — | — | US | disclosed |
| US-20030045545-A1 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY | 2003-03-06 | — | — | US | disclosed |
| US-6440992-B1 | ARE IMMUNOMODULATORS AND INDUCE CYTOKINE BIOSYNTHESIS, INCLUDING INTERFERON AND/OR TUMOR BIOSYNTHESIS, NECROSIS FACTOR, AND INHIBIT T-HELPER-TYPE 2 IMMUNE RESPONSE; USEFUL FOR THERAPY OF VIRAL AND NEOPLASTIC DISEASES | 3M INNOVATIVE PROPERTIES COMPANY | 2002-08-27 | — | — | US | disclosed |
| US-20020072528-A1 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY | 2002-06-13 | — | — | US | disclosed |
| US-6323200-B1 | THE COMPOUNDS ARE IMMUNOMODULATORS AND INDUCE CYTOKINE BIOSYNTHESIS, INCLUDING INTERFERON AND/OR TUMOR BIOSYNTHESIS, NECROSIS FACTOR, AND INHIBIT THE T-HELPER-TYPE 2 IMMUNE RESPONSE. | 3M INNOVATIVE PROPERTIES COMPANY | 2001-11-27 | — | — | US | disclosed |
| EP-1100802-A1 | OXAZOLO, THIAZOLO AND SELENAZOLO [4,5-c]-QUINOLIN-4-AMINES AND ANALOGS THEREOF | 3M Innovative Properties Company (US) | 2001-05-23 | — | — | EP | disclosed |
| US-6110929-A | IMMUNOMODULATORS WHICH INDUCE CYTOKINE BIOSYNTHESIS, INCLUDING INTERFERON AND/OR TUMOR BIOSYNTHESIS, NECROSIS FACTOR AND INHIBIT T-HELPER-TYPE 2 IMMUNE RESPONSE; FOR TREATMENT OF VIRAL AND NEOPLASTIC DISEASES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2000-08-29 | — | — | US | disclosed |
| WO-2000006577-A1 | OXAZOLO, THIAZOLO AND SELENAZOLO [4,5-c]-QUINOLIN-4-AMINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020072528-A1 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof | IFNG, THPO, IL2 | ALDH1A1 2933/4885HPGD 496/4885MAPT 3980/4885 |
| US-20030065006-A1 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof | IFNG, THPO, IL2 | ALDH1A1 2933/4885HPGD 496/4885MAPT 3980/4885 |
| US-20100234421-A1 | SUBSTITUTED 3-AMINO-2-MERCAPTOQUINOLINES AS KCNQ2/3 MODULATORS | KCNQ1, KCNQ2, KCNQ3 | ALDH1A1 2790/4885HPGD 3043/4885MAPT 4236/4885 |
| US-20030045545-A1 | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof | IFNG, THPO, IL2 | ALDH1A1 2933/4885HPGD 496/4885MAPT 3980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.