Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.60 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118687 | 0.88 | KDM4E (0.78) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL823908 | 0.88 | ALDH1A1 (0.78) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL2583451 | 0.84 | KDM4E (0.73) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL5454067 | 0.84 | KDM4E (0.73) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL9472025 | 0.84 | KDM4E (0.73) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL31208294 | 0.84 | KDM4E (0.73) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL2316982 | 0.82 | KDM4E (0.69) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL9683724 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL10393915 | 0.82 | KDM4E (0.69) | ALDH1A1KDM4ECREBBPSMYD3NOS1 | |
| SCHEMBL12266541 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4ECREBBPSMYD3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12391690-B2 | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | LIGACHEM BIOSCIENCES INC. (KR) | 2025-08-19 | — | — | US | disclosed |
| CN-116134035-B | 3- (1H-imidazol-2-yl) -2,3,8 a-tetrahydroindol-5 (1H) -one derivatives useful as factor XIA inhibitors | 詹森药业有限公司 | 2025-03-11 | — | — | CN | disclosed |
| US-20230295157-A1 | 3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS | JANSSEN RESEARCH & DEVELOPMENT, LLC | 2023-09-21 | — | — | US | disclosed |
| EP-4185588-A1 | 3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS | Janssen Pharmaceutica NV (BE) | 2023-05-31 | — | — | EP | disclosed |
| US-20230123569-A1 | COMPOUNDS AS AUTOTAXIN INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | LIGACHEM BIOSCIENCES INC. (KR) | 2023-04-20 | — | — | US | disclosed |
| US-11548883-B2 | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | LEGOCHEM BIOSCIENCES, INC. (KR) | 2023-01-10 | — | — | US | disclosed |
| EP-3442973-B1 | NOVEL COMPOUNDS AS AUTOTAXIN INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | LEGOCHEM BIOSCIENCES INC (KR) | 2022-08-31 | — | — | EP | disclosed |
| CN-109476664-B | Novel compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | 乐高化学生物科学股份有限公司 | 2021-08-10 | — | — | CN | disclosed |
| US-10961242-B2 | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | LEGOCHEM BIOSCIENCES, INC. (KR) | 2021-03-30 | — | — | US | disclosed |
| US-10889575-B2 | 4,4-diphenylpiperidine compounds or pharmaceutically acceptable salts thereof, pharmaceutical compositions and uses thereof | ACADEMY OF MILITARY MEDICAL SCIENCES (CN) | 2021-01-12 | — | — | US | disclosed |
| WO-2004074272-A1 | ANTHELMINTIC AGENTS AND INSECTICIDAL COMPOSITIONS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-09-02 | — | — | WO | disclosed |
| US-20040171650-A1 | Novel anthelmintic and insecticidal compositions | LEE BYUNG HYUN (US) | 2004-09-02 | — | — | US | disclosed |
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |
| US-4816457-A | HYPOTENSIVE AGENTS, BRONCHODILATORS, EYES | MERCK & CO., INC., A CORP. OF NJ | 1989-03-28 | — | — | US | disclosed |
| US-4686222-A | ADRENERGIC BLOCKERS, BRONCHODILATORS | MERCK & CO., INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4568679-A | ADRENERGIC BLOCKING AGENTS, HYPOTENSIVE AGENTS, BRONCHODILATOR AGENTS, REDUCING INTRAOCULAR PRESSURE | MERCK & CO., INC. (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0105053-A1 | Aralkylaminoethanol heterocyclic compounds | MERCK & CO. INC. (US) | 1984-04-11 | — | — | EP | disclosed |
| US-4358455-A | GLAUCOMA, HYPOTENSIVE, ANTIARRHYTHMIA, BRONCHODILATORS | MERCK & CO., INC. (US) | 1982-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548883-B2 | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | ENPP2, PLA2G10, LPCAT1 | ALDH1A1 4207/4885KDM4E 3095/4885CREBBP 3867/4885 |
| US-10889575-B2 | 4,4-diphenylpiperidine compounds or pharmaceutically acceptable salts thereof, pharmaceutical compositions and uses thereof | CACNA1B, CACNA1D, TRPV4 | ALDH1A1 250/4885KDM4E 758/4885CREBBP 1243/4885 |
| US-20230123569-A1 | COMPOUNDS AS AUTOTAXIN INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | ENPP2, PLA2G10, LPCAT1 | ALDH1A1 4207/4885KDM4E 3095/4885CREBBP 3867/4885 |
| US-20230295157-A1 | 3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS | SERPINC1, F11, TFPI2 | ALDH1A1 2661/4885KDM4E 1528/4885CREBBP 4514/4885 |
| US-12391690-B2 | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | ENPP2, PLA2G10, LPCAT1 | ALDH1A1 4207/4885KDM4E 3095/4885CREBBP 3867/4885 |
| US-10961242-B2 | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same | ENPP2, PLA2G10, LPCAT1 | ALDH1A1 4207/4885KDM4E 3095/4885CREBBP 3867/4885 |
| US-20040171650-A1 | Novel anthelmintic and insecticidal compositions | ACHE, AADAC, BCHE | ALDH1A1 2861/4885KDM4E 1321/4885CREBBP 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.