SCHEMBL1728362

SCHEMBL1728362

O=c1nc2c(-c3ccccc3Cl)c(-c3ccccc3Cl)nc-2c1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GLA P06280 1/20 0.37
MAOB P27338 1/20 0.37
MAT2A P31153 1/20 0.36
KMT2A Q03164 1/20 0.36
HSP90AA1 P07900 1/20 0.36
HSP90AB1 P08238 1/20 0.36
GUSB P08236 1/20 0.36
C1R P00736 1/20 0.36
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36
NOTUM Q6P988 1/20 0.35
DCUN1D1 Q96GG9 1/20 0.35
ELANE P08246 1/20 0.35
CNR1 P21554 1/20 0.35
CYP2A6 P11509 1/20 0.34
NPC1 O15118 1/20 0.34
TP53 P04637 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL38657449 0.80 RXRA (0.40) ALDH1A1KMT2APTGS1PTGS2NOTUM
SCHEMBL6545475 0.76 KDM4E (0.44) KDM4EALDH1A1GLAMAOBKMT2A
SCHEMBL27639805 0.73 ALDH1A1 (0.42) KDM4EALDH1A1GLAKMT2AHSP90AA1
SCHEMBL5451049 0.69 ALOX15 (0.44) KDM4EALDH1A1GLAMAOBKMT2A
SCHEMBL643990 0.66 ADORA2A (0.42) KDM4EALDH1A1NPC1HPGDRAB9A
SCHEMBL24122662 0.64 KMT2A (0.52) KDM4EALDH1A1GLAKMT2AGUSB
SCHEMBL7846078 0.62 KDM4E (0.50) KDM4EALDH1A1GLAKMT2AGUSB
SCHEMBL8119337 0.62 SCN9A (0.50) KMT2ANOTUM
SCHEMBL2469822 0.62 CYP2A6 (0.55) ALDH1A1KMT2ANOTUMCYP2A6NPC1
SCHEMBL15532937 0.61 CNR1 (0.44) KDM4EALDH1A1GLAKMT2AHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012027650-A3 PALLET DESIGN WITH BUOYANT CHARACTERISTICS ORIA COLLAPSIBLES, LLC (US) 2012-05-10 WO disclosed
EP-2212386-B1 DIKETOPYRROLOPYRROLE COCRYSTALS CLARIANT FINANCE BVI LTD (VG) 2011-11-30 EP disclosed