SCHEMBL1728937

SCHEMBL1728937

N=C(NC(=O)OCc1ccccc1)n1cccn1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.50
SMN1; SMN2 Q16637 2/20 0.43
LMNA P02545 1/20 0.43
MGLL Q99685 1/20 0.42
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
HTT P42858 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6623569 0.85 RAB9A (0.42) RAB9AHTT
SCHEMBL9254620 0.84 POLB (0.47) POLBSMN1; SMN2LMNACA12CA1
SCHEMBL22798569 0.81 POLB (0.44) POLBSMN1; SMN2LMNACA12CA1
SCHEMBL8196306 0.81 POLB (0.44) POLBSMN1; SMN2LMNACA12CA1
SCHEMBL670165 0.80 POLB (0.43) POLBSMN1; SMN2LMNACA12CA1
SCHEMBL670164 0.80 POLB (0.43) POLBSMN1; SMN2LMNACA12CA1
SCHEMBL5567091 0.80 POLB (0.43) POLBSMN1; SMN2LMNACA12CA1
SCHEMBL15500843 0.79 L3MBTL1 (0.48) POLBSMN1; SMN2NPC1RAB9A
SCHEMBL25325183 0.78 NPC1 (0.43) NPC1RAB9A
SCHEMBL9823 0.76 ALDH1A1 (0.40) POLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4655289-A1 SINGLE-MOLECULE PEPTIDE SEQUENCING USING GUANIDINYLATING AGENTS Glyphic Biotechnologies, Inc. (US) 2025-12-03 EP disclosed
CN-119522092-A Multivalent molecule-based lipid nanoparticles for nucleic acid delivery 比奥-特里普公司 2025-02-25 CN disclosed
WO-2024159162-A1 SINGLE-MOLECULE PEPTIDE SEQUENCING USING GUANIDINYLATING AGENTS GLYPHIC BIOTECHNOLOGIES, INC. (US) 2024-08-02 WO disclosed
US-11935803-B2 Resin composition, laminate, semiconductor wafer with resin composition layer, substrate for mounting semiconductor with resin composition layer and semiconductor device MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2024-03-19 US disclosed
WO-2023233042-A1 POLYVALENT MOLECULE BASED LIPID NANOPARTICLES FOR NUCLEIC ACID DELIVERY BIO-TRIP B.V. (NL) 2023-12-07 WO disclosed
US-11788080-B2 Modified cleavases, uses thereof and related kits Encodia, Inc. (US) 2023-10-17 US disclosed
US-11788080-B2 Modified cleavases, uses thereof and related kits Encodia, Inc. (US) 2023-10-17 US disclosed
US-11782062-B2 Kits for analysis using nucleic acid encoding and/or label Encodia, Inc. (US) 2023-10-10 US disclosed
US-11782062-B2 Kits for analysis using nucleic acid encoding and/or label Encodia, Inc. (US) 2023-10-10 US disclosed
US-20230257727-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-08-17 US disclosed
CN-1744916-A Preventive or remedy for diseases caused by hyperglycemia KISSEI PHARMACEUTICAL (JP) 2006-03-08 CN disclosed
US-20060035844-A1 Preventive or remedy for diseases caused by hyperglycemia KISSEI PHARMACEUTICAL CO., LTD. (JP) 2006-02-16 US disclosed
EP-1609798-A1 FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF Kissei Pharmaceutical Co., Ltd. (JP) 2005-12-28 EP disclosed
US-20050272669-A1 Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof KISSEI PHARMACEUTICAL CO., LTD. (JP) 2005-12-08 US disclosed
EP-1568380-A1 PREVENTIVE OR REMEDY FOR DISEASES CAUSED BY HYPERGLYCEMIA Kissei Pharmaceutical Co., Ltd. (JP) 2005-08-31 EP disclosed
EP-1548024-A1 PYRAZOLE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF Kissei Pharmaceutical Co., Ltd. (JP) 2005-06-29 EP disclosed
EP-1373216-B1 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY SOLVAY PHARM BV (NL) 2004-12-15 EP disclosed
CN-1486301-A 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity ������ҩ�����޹�˾ 2004-03-31 CN disclosed
US-6476060-B2 DRUG ABUSE; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; CARDIOVASCUALR DISORDERS SOLVAY PHARMACEUTICALS, B.V. (NL) 2002-11-05 US disclosed
US-20010053788-A1 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity SOLVAY PHARMACEUTICALS B.V. 2001-12-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010053788-A1 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity CNR1, CNR2, CBR3 POLB 4164/4885SMN1; SMN2 4520/4885LMNA 4585/4885
US-20050272669-A1 Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof UGGT1, GCKR, SLC5A1 POLB 4523/4885SMN1; SMN2 4382/4885LMNA 2896/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.