Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7253798 | 0.82 | L3MBTL1 (0.71) | HTR5AMEN1KMT2AL3MBTL1CYP1A2 | |
| SCHEMBL1728674 | 0.81 | ALDH1A1 (0.60) | MEN1KMT2AL3MBTL1KDM4EDRD2 | |
| SCHEMBL1728438 | 0.81 | LTA4H (0.56) | HRH1LTA4HMCHR1MCHR2KCNH2 | |
| SCHEMBL6083117 | 0.81 | DRD2 (0.59) | HTR1ADRD2HTR2AHRH1DRD3 | |
| SCHEMBL6081563 | 0.80 | LTA4H (0.55) | LTA4HMCHR1MCHR2KCNH2HRH3 | |
| SCHEMBL1728503 | 0.79 | LTA4H (0.54) | KDM4ELTA4HMCHR1MCHR2KCNH2 | |
| SCHEMBL1728498 | 0.79 | LTA4H (0.51) | KDM4EHRH1LTA4HMCHR1MCHR2 | |
| SCHEMBL1729170 | 0.79 | LTA4H (0.51) | HRH1LTA4HMCHR1MCHR2MAOA | |
| SCHEMBL1728694 | 0.79 | KDM4E (0.56) | KMT2AKDM4ELTA4HMCHR1MCHR2 | |
| SCHEMBL6081461 | 0.77 | HRH3 (0.52) | LTA4HMCHR1MCHR2KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |