Ethylene Glycol

Ethylene Glycol

SCHEMBL17292672

C=Cc1cccc(O)c1O.OCCO

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.52
POLB P06746 6/20 0.50
GAA P10253 5/20 0.50
RAB9A P51151 1/20 0.50
ALDH1A1 P00352 4/20 0.44
HPGD P15428 3/20 0.44
ALOX15 P16050 3/20 0.44
HSD17B10 Q99714 3/20 0.44
TDP1 Q9NUW8 3/20 0.44
RECQL P46063 3/20 0.44
LMNA P02545 2/20 0.44
ADAMTS4 O75173 1/20 0.44
EGFR P00533 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
FYN P06241 1/20 0.44
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44
MMP8 P22894 1/20 0.44
CA6 P23280 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29356117 0.91 ERN1 (0.60) ERN1POLBGAARAB9AALDH1A1
SCHEMBL131222 0.91 ERN1 (0.60) ERN1POLBGAARAB9AALDH1A1
Acetone SCHEMBL22719929 0.82 ERN1 (0.61) ERN1POLBGAARAB9AALDH1A1
Sulfuric Acid SCHEMBL9048559 0.82 ERN1 (0.55) ERN1POLBGAARAB9AALDH1A1
SCHEMBL4962062 0.79 ALDH1A1 (0.46) ERN1POLBGAARAB9AALDH1A1
Acetic Acid SCHEMBL724536 0.79 ERN1 (0.57) ERN1POLBGAARAB9AALDH1A1
Ethylene Glycol SCHEMBL640721 0.77 ALDH1A1 (0.50) ALDH1A1HPGDHSD17B10TDP1RECQL
Pyrogallol SCHEMBL28732500 0.77 ALDH1A1 (0.75) ERN1POLBGAARAB9AALDH1A1
Ethylene Glycol SCHEMBL4453630 0.76 ALDH1A1 (0.39) ALDH1A1HPGDHSD17B10
SCHEMBL4850054 0.74 ERN1 (0.56) ERN1POLBGAARAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3270949-A2 INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH Case Western Reserve University (US) 2018-01-24 EP claimed
WO-2016149222-A2 INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH CASE WESTERN RESERVE UNIVERSITY (US) 2016-09-22 WO claimed
EP-3148662-B1 EXTRACTION, DERIVATIZATION, AND QUANTIFICATION OF ANALYTES TECAN SP INC (US) 2025-10-15 EP disclosed
EP-3270949-B1 INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH UNIV CASE WESTERN RESERVE (US) 2025-01-29 EP disclosed
US-20240218041-A1 MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-07-04 US disclosed
EP-4334338-A1 MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES The Trustees of Indiana University (US) 2024-03-13 EP disclosed
US-20230399373-A1 MOLECULAR DESIGNS OF GLUCOSE-RESPONSIVE AND GLUCOSE-CLEAVABLE INSULIN ANALOGUES THE TRUSTEES OF INDIANA UNIVERSITY 2023-12-14 US disclosed
EP-4232464-A1 MOLECULAR DESIGNS OF GLUCOSE-RESPONSIVE AND GLUCOSE-CLEAVABLE INSULIN ANALOGUES The Trustees of Indiana University (US) 2023-08-30 EP disclosed
US-11739345-B2 Methods of treating phenylketonuria BIOMARIN PHARMACEUTICAL INC. (US) 2023-08-29 US disclosed
WO-2022235691-A1 MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES THE TRUSTEES OF INDIANA UNIVERSITY (US) 2022-11-10 WO disclosed
US-20220288213-A1 INSULIN ANALOGUES WITH GLUCOSE REGULATED CONFORMATIONAL SWITCH THERMALIN INC (US) 2022-09-15 US disclosed
EP-3790627-A2 METHODS OF TREATING PHENYLKETONURIA BioMarin Pharmaceutical Inc. (US) 2021-03-17 EP disclosed
US-10584156-B2 Insulin analogues with a glucose-regulated conformational switch CASE WESTERN RESERVE UNIVERSITY (US) 2020-03-10 US disclosed
WO-2019217513-A2 METHODS OF TREATING PHENYLKETONURIA BIOMARIN PHARMACEUTICAL INC. (US) 2019-11-14 WO disclosed
US-10267775-B2 Extraction, derivatization, and quantification of analytes TECAN SP, INC. (US) 2019-04-23 US disclosed
US-20180057559-A1 INSULIN ANALOGUES WITH A GLUCOSE-REGULATED CONFORMATIONAL SWITCH CASE WESTERN RESERVE UNIVERSITY 2018-03-01 US disclosed
EP-3270949-A2 INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH Case Western Reserve University (US) 2018-01-24 EP disclosed
EP-3148662-A1 EXTRACTION, DERIVATIZATION, AND QUANTIFICATION OF ANALYTES SPEware Corporation (US) 2017-04-05 EP disclosed
WO-2016149222-A2 INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL SWITCH CASE WESTERN RESERVE UNIVERSITY (US) 2016-09-22 WO disclosed
US-20150346170-A1 Extraction, Derivatization, and Quantification of Analytes QUANTALYTICAL LABS INC. (US) 2015-12-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220288213-A1 INSULIN ANALOGUES WITH GLUCOSE REGULATED CONFORMATIONAL SWITCH IAPP, GPR119, INSR ERN1 247/4885POLB 3425/4885GAA 242/4885
US-20240218041-A1 MOLECULAR DESIGN OF GLUCOSE SENSORS IN GLUCOSE-RESPONSIVE INSULIN ANALOGUES IAPP, GPR119, INSR ERN1 1160/4885POLB 3122/4885GAA 2154/4885
US-11739345-B2 Methods of treating phenylketonuria PAH, PNMT, AADAT ERN1 2956/4885POLB 1744/4885GAA 36/4885
US-20230399373-A1 MOLECULAR DESIGNS OF GLUCOSE-RESPONSIVE AND GLUCOSE-CLEAVABLE INSULIN ANALOGUES IAPP, GPR119, INSR ERN1 589/4885POLB 1797/4885GAA 203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.