Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17308624 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL17308684 | 1.00 | SLC7A5 (0.43) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL19085619 | 0.86 | SLC7A5 (0.41) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL19997403 | 0.86 | SLC7A5 (0.41) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL19085728 | 0.86 | SLC7A5 (0.41) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL17308685 | 0.85 | SLC7A5 (0.47) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL19085618 | 0.83 | CYP1A2 (0.33) | SLC7A5CYP3A4HSD17B10 | |
| SCHEMBL17308623 | 0.81 | SLC7A5 (0.42) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL19085586 | 0.81 | SLC7A5 (0.41) | SLC7A5CYP3A4PKMPTGS1ALPI | |
| SCHEMBL17308674 | 0.81 | CYP2C19 (0.32) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106573895-B | Novel 5-acylsulfanyl-histidine compounds as precursors for the corresponding 5-sulfanylhistidines and disulfides thereof | 特瑞海德公司 | 2020-11-24 | — | — | CN | claimed |
| US-9926300-B2 | 5-acylsulfanyl-histidine compounds as precursors of the corresponding 5-sulfanylhistidines and their disulfides | TETRAHEDRON (FR) | 2018-03-27 | — | — | US | claimed |
| US-20170190691-A1 | NOVEL 5-ACYLSULFANYL-HISTIDINE COMPOUNDS AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THEIR DISULFIDES | TETRAHEDRON (FR) | 2017-07-06 | — | — | US | claimed |
| CN-106573895-A | Novel 5-acylsulfanyl-histidine compounds as precursors for the corresponding 5-sulfanylhistidines and disulfides thereof | 特瑞海德公司 | 2017-04-19 | — | — | CN | claimed |
| EP-3148973-A1 | NOVEL COMPOUNDS OF THE 5-ACYLSULFANYL-HISTIDINE TYPE AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THE DISULFIDES THEREOF | Tetrahedron (FR) | 2017-04-05 | — | — | EP | claimed |
| WO-2015181507-A1 | NOVEL COMPOUNDS OF THE 5-ACYLSULFANYL-HISTIDINE TYPE AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THE DISULFIDES THEREOF | TETRAHEDRON (FR) | 2015-12-03 | — | — | WO | claimed |
| EP-3666760-B1 | 5-THIOISTIDINE COMPOUNDS AND METHYLATED DERIVATIVES (OVOTHIOLS) AS INHIBITORS OF GAMMA-GLUTAMYL-TRANSPEPTIDASE (GGT) ACTIVITY | STAZIONE ZOOLOGICA ANTON DOHRN (IT) | 2023-07-26 | — | — | EP | disclosed |
| EP-4166658-A1 | DIATOM-BASED GENETIC ENGINEERING SYSTEM METHODOLOGY FOR THE ECO-SUSTAINABLE PRODUCTION OF OVOTHIOLS | Stazione Zoologica Anton Dohrn (IT) | 2023-04-19 | — | — | EP | disclosed |
| EP-3684355-B1 | OVOTHIOLS FOR THE TREATMENT OF CHRONIC LOW GRADE SYSTEMIC INFLAMMATION (CLGSI) AND RELATED DISEASES | UNIV DEGLI STUDI G DANNUNZIO CHIETI PESCARA (IT) | 2021-09-08 | — | — | EP | disclosed |
| CN-112194632-A | Novel 5-acylsulfanyl-histidine compounds as precursors for the corresponding 5-sulfanylhistidines and disulfides thereof | 特瑞海德公司 | 2021-01-08 | — | — | CN | disclosed |
| CN-106573895-B | Novel 5-acylsulfanyl-histidine compounds as precursors for the corresponding 5-sulfanylhistidines and disulfides thereof | 特瑞海德公司 | 2020-11-24 | — | — | CN | disclosed |
| US-20200276165-A1 | OVOTIOLS FOR THE TREATMENT OF CHRONIC LOW-GRADE SYSTEMIC INFLAMMATION (CLGSI) AND RELATED DISEASES | UNIVERSITA' DEGLI STUDI G. D'ANNUNZIO CHIETI - PESCARA (IT) | 2020-09-03 | — | — | US | disclosed |
| EP-3666760-A1 | 5-THIOISTIDINE COMPOUNDS AND METHYLATED DERIVATIVES (OVOTHIOLS) AS INHIBITORS OF GAMMA-GLUTAMYL-TRANSPEPTIDASE (GGT) ACTIVITY | Stazione Zoologica "Anton Dohrn" (IT) | 2020-06-17 | — | — | EP | disclosed |
| US-20170190691-A1 | NOVEL 5-ACYLSULFANYL-HISTIDINE COMPOUNDS AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THEIR DISULFIDES | TETRAHEDRON (FR) | 2017-07-06 | — | — | US | disclosed |
| US-20170190691-A1 | NOVEL 5-ACYLSULFANYL-HISTIDINE COMPOUNDS AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THEIR DISULFIDES | TETRAHEDRON (FR) | 2017-07-06 | — | — | US | disclosed |
| US-20170190691-A1 | NOVEL 5-ACYLSULFANYL-HISTIDINE COMPOUNDS AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THEIR DISULFIDES | TETRAHEDRON (FR) | 2017-07-06 | — | — | US | disclosed |
| CN-106573895-A | Novel 5-acylsulfanyl-histidine compounds as precursors for the corresponding 5-sulfanylhistidines and disulfides thereof | 特瑞海德公司 | 2017-04-19 | — | — | CN | disclosed |
| EP-3148973-A1 | NOVEL COMPOUNDS OF THE 5-ACYLSULFANYL-HISTIDINE TYPE AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THE DISULFIDES THEREOF | Tetrahedron (FR) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181507-A1 | NOVEL COMPOUNDS OF THE 5-ACYLSULFANYL-HISTIDINE TYPE AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THE DISULFIDES THEREOF | TETRAHEDRON (FR) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015181507-A1 | NOVEL COMPOUNDS OF THE 5-ACYLSULFANYL-HISTIDINE TYPE AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THE DISULFIDES THEREOF | TETRAHEDRON (FR) | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190691-A1 | NOVEL 5-ACYLSULFANYL-HISTIDINE COMPOUNDS AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THEIR DISULFIDES | AHCYL1, CBS, H1-5 | SLC7A5 79/4885CYP3A4 2019/4885PKM 3434/4885 |
| US-20200276165-A1 | OVOTIOLS FOR THE TREATMENT OF CHRONIC LOW-GRADE SYSTEMIC INFLAMMATION (CLGSI) AND RELATED DISEASES | PTGIS, PTGES, AREG | SLC7A5 3262/4885CYP3A4 3696/4885PKM 3095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.