Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | DRD3 | P35462 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729120 | 0.87 | F10 (0.44) | DRD2DRD3HTR2AHTR1ADRD4 | |
| SCHEMBL1727927 | 0.84 | HRH4 (0.44) | DRD2DRD3DRD4HTR2CACACB | |
| SCHEMBL1727922 | 0.81 | DRD2 (0.46) | DRD2DRD3HTR2AHTR1AADRB2 | |
| SCHEMBL1729971 | 0.81 | CYP11B2 (0.42) | DRD2HTR2AHTR1AACACBACACA | |
| SCHEMBL1728883 | 0.80 | MAP4K4 (0.44) | KCNH2ACACBACACA | |
| SCHEMBL1730192 | 0.80 | CKS1B (0.46) | ACACBACACA | |
| SCHEMBL1728164 | 0.80 | KDM4E (0.45) | KCNH2ACACBACACA | |
| SCHEMBL1730124 | 0.79 | CHRM4 (0.46) | DRD2DRD3HTR2AHTR2C | |
| SCHEMBL1727745 | 0.79 | RXRA (0.46) | — | |
| SCHEMBL3265695 | 0.77 | SIRT2 (0.45) | DRD2DRD3HTR2AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |