SCHEMBL1732991

SCHEMBL1732991

CCC1C(=O)NC(=S)N(CC)C1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.40
MAPT P10636 6/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
KDM4E B2RXH2 2/20 0.38
PKM P14618 1/20 0.38
HPGD P15428 1/20 0.38
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
LMNA P02545 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
GAA P10253 2/20 0.34
IDH1 O75874 2/20 0.33
CNR1 P21554 1/20 0.33
F2 P00734 1/20 0.33
ELANE P08246 1/20 0.33
CTSG P08311 1/20 0.33
CTRC Q99895 1/20 0.33
P2RX3 P56373 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1426485 0.82 LMNA (0.41) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL11822220 0.79 NPSR1 (0.40) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL11739099 0.79 NPSR1 (0.40) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL3487989 0.73 ALDH1A1 (0.39) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL11741035 0.70 GAA (0.51) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL9334188 0.69 F2 (0.46) ALDH1A1MAPTMEN1KMT2ACYP2C9
SCHEMBL20607282 0.69 SMN1; SMN2 (0.41) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL11168067 0.69 ALDH1A1 (0.63) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL14490041 0.69 F2 (0.43) ALDH1A1MAPTKDM4EHPGDLMNA
SCHEMBL2853254 0.69 F2 (0.57) ALDH1A1MAPTKDM4EHPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9173826-B2 Porous, dissolvable solid substrate and surface resident coating comprising a zync pyrithione THE PROCTER & GAMBLE COMPANY (US) 2015-11-03 US disclosed
US-20140113971-A1 Topical NSAID Compositions Having Sensate Component ZHANG JOANNA (US) 2014-04-24 US disclosed
US-8631970-B2 Multi-chamber material dispensing system and method for making same THE PROCTER & GAMBLE COMPANY (US) 2014-01-21 US disclosed
US-8586017-B2 Self-heating non-aerosol shave product THE GILLETTE COMPANY (US) 2013-11-19 US disclosed
EP-2536386-A1 A POROUS, DISSOLVABLE SOLID SUBSTRATE AND SURFACE RESIDENT COATING COMPRISING A ZYNC PYRITHIONE The Procter & Gamble Company (US) 2012-12-26 EP disclosed
EP-1778160-B1 SELF-HEATING NON-AEROSOL SHAVE PRODUCT GILLETTE CO (US) 2012-11-21 EP disclosed
EP-2509562-A2 POROUS, DISSOLVABLE SOLID SUBSTRATE AND SURFACE RESIDENT COATING COMPRISING A SKIN TREATMENT ACTIVE The Gillette Company (US) 2012-10-17 EP disclosed
US-8221734-B2 Self-heating shaving compositions THE PROCTER & GAMBLE COMPANY (US) 2012-07-17 US disclosed
EP-1776162-B1 SELF-HEATING SHAVE FOAM PRODUCT GILLETTE CO (US) 2011-11-30 EP disclosed
US-20110237674-A1 TOPICAL NSAID COMPOSITIONS HAVING SENSATE COMPONENT NOVARTIS AG (CH) 2011-09-29 US disclosed
WO-2010028343-A2 SELF-HEATING SHAVING COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2010-03-11 WO disclosed
EP-1778160-A1 SELF-HEATING NON-AEROSOL SHAVE PRODUCT THE GILLETTE COMPANY (US) 2007-05-02 EP disclosed
EP-1776162-A1 SELF-HEATING SHAVE FOAM PRODUCT THE GILLETTE COMPANY (US) 2007-04-25 EP disclosed
WO-2006020420-A1 SELF-HEATING NON-AEROSOL SHAVE PRODUCT THE GILLETTE COMPANY (US) 2006-02-23 WO disclosed
WO-2006020418-A1 SELF-HEATING SHAVE FOAM PRODUCT THE GILLETTE COMPANY (US) 2006-02-23 WO disclosed
US-20060029565-A1 Self-heating shave foam product THE GILLETTE COMPANY 2006-02-09 US disclosed
US-20060029566-A1 Self-heating non-aerosol shave product THE GILLETTE COMPANY 2006-02-09 US disclosed
EP-0411220-A1 Autogenously heated liquid soap composition Colgate-Palmolive Company (US) 1991-02-06 EP disclosed
US-4839081-A Autogenously heated liquid soap composition COLGATE-PALMOLIVE COMPANY (US) 1989-06-13 US disclosed
US-4004711-A Disposable towel GORHAM INTERNATIONAL INC. (US) 1977-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110237674-A1 TOPICAL NSAID COMPOSITIONS HAVING SENSATE COMPONENT TRPA1, TRPV1, PTGES ALDH1A1 971/4885MAPT 1491/4885MEN1 3419/4885
US-20140113971-A1 Topical NSAID Compositions Having Sensate Component TRPA1, TRPV1, PTGES ALDH1A1 971/4885MAPT 1491/4885MEN1 3419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.