SCHEMBL173528

SCHEMBL173528

O=C(O)c1ccc2nccn2c1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.52
NAMPT P43490 10/20 0.50
MEN1 O00255 1/20 0.49
CYP1A2 P05177 1/20 0.49
KMT2A Q03164 1/20 0.49
ESR1 P03372 1/20 0.48
MCHR1 Q99705 1/20 0.48
KEAP1 Q14145 1/20 0.47
DYRK1A Q13627 1/20 0.47
S1PR3 Q99500 1/20 0.45
HDAC1 Q13547 1/20 0.44
RET P07949 1/20 0.44
CYP2C9 P11712 1/20 0.43
HSD11B1 P28845 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL15232009 0.98 MAOB (0.51) MAOBNAMPTMEN1CYP1A2KMT2A
SCHEMBL20641173 0.86 DYRK1A (0.63) MAOBNAMPTMEN1CYP1A2KMT2A
SCHEMBL28407576 0.86 MAOB (0.50) MAOBNAMPTMEN1CYP1A2KMT2A
SCHEMBL12327197 0.84 MAOB (0.51) MAOBNAMPTMEN1CYP1A2KMT2A
SCHEMBL160745 0.84 MAOB (0.51) MAOBNAMPTMEN1CYP1A2KMT2A
SCHEMBL15038280 0.84 MAOB (0.55) MAOBNAMPTMEN1CYP1A2KMT2A
Hydrochloric Acid SCHEMBL30259053 0.82 MAOB (0.50) MAOBNAMPTMEN1CYP1A2KMT2A
SCHEMBL15377241 0.81 MCHR1 (0.55) MAOBNAMPTMEN1KMT2AMCHR1
SCHEMBL15246316 0.81 NAMPT (0.73) NAMPTHDAC1CYP2C9
SCHEMBL24087277 0.80 MAOB (0.48) MAOBNAMPTMEN1CYP1A2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 357 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119661811-A Latent accelerator based on anhydride-tertiary amine dynamic ion pair, preparation method and application thereof 江南大学 2025-03-21 CN claimed
EP-2820017-B1 PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES GENENTECH INC (US) 2016-12-21 EP claimed
EP-2310356-B1 ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME LUNDBECK & CO AS H (DK) 2013-08-14 EP claimed
JP-2011529057-A 2011-12-01 JP claimed
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE ADDEX PHARMA SA (CH) 2010-09-30 US claimed
WO-2010011570-A1 ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME H. LUNDBECK A/S (DK) 2010-01-28 WO claimed
US-20100022546-A1 ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME H. LUNDBECK A/S (DK) 2010-01-28 US claimed
EP-2134676-A2 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE Addex Pharma SA (CH) 2009-12-23 EP claimed
WO-2008117175-A2 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE ADDEX PHARMA SA (CH) 2008-10-02 WO claimed
EP-3856179-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-05-13 EP disclosed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 EP disclosed
US-12336981-B2 Compounds and compositions for the inhibition of NAMPT VALO HEALTH, INC. (US) 2025-06-24 US disclosed
WO-2025122558-A1 PYRAZINAMIDE-MIMICKING SMALL MOLECULES AS TREATMENT FOR TUBERCULOSIS UNIVERSITY OF MARYLAND, BALTIMORE (US) 2025-06-12 WO disclosed
US-20040167160-A1 Retinoid x receptor modulators LIGAND PHARMACEUTICALS INCORPORATED 2004-08-26 US disclosed
WO-2004046144-A1 8-SUBSTITUTED IMIDAZOPYRIDINES ALTANA PHARMA AG (DE) 2004-06-03 WO disclosed
EP-1373240-A2 RETINOID X RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2004-01-02 EP disclosed
US-20030236264-A1 Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease PHARMACIA & UPJOHN COMPANY 2003-12-25 US disclosed
WO-2003070732-A1 FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE PHARMACIA & UPJOHN COMPANY (US) 2003-08-28 WO disclosed
WO-2002071827-A2 RETINOID X RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2002-09-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040167160-A1 Retinoid x receptor modulators RXRA, RXRG, RXRB MAOB 1942/4885NAMPT 643/4885MEN1 4117/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH MAOB 165/4885NAMPT 4738/4885MEN1 4537/4885
US-20030236264-A1 Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease NAT1, CYP11B1, COASY MAOB 326/4885NAMPT 353/4885MEN1 220/4885
US-12336981-B2 Compounds and compositions for the inhibition of NAMPT NAMPT, NNMT, NNT MAOB 105/4885NAMPT 1/4885MEN1 491/4885
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE FSHR, GNRHR, SHBG MAOB 1018/4885NAMPT 3096/4885MEN1 150/4885
US-20100022546-A1 ADAMANTYL DIAMIDE DERIVATIVES AND USES OF SAME QDPR, ADM2, PDE3B MAOB 1846/4885NAMPT 2310/4885MEN1 67/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.