SCHEMBL17366376

SCHEMBL17366376

Clc1ccc(/C=C/C=N/N(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
G6PC1 P35575 1/20 0.41
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
MAOB P27338 3/20 0.39
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.38
NFE2L2 Q16236 1/20 0.38
GRIN1 Q05586 2/20 0.37
GRIN2B Q13224 2/20 0.37
MAOA P21397 1/20 0.37
MAPT P10636 2/20 0.37
GRIN2D O15399 1/20 0.37
GRIN3B O60391 1/20 0.37
GRIN2A Q12879 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17367920 0.83 ALDH1A1 (0.54) ALDH1A1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL17366360 0.82 MAOB (0.45) ALDH1A1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL17366375 0.79 G6PC1 (0.57) ALDH1A1MEN1KMT2AG6PC1CYP1A2
SCHEMBL17366359 0.76 TLR4 (0.39) ALDH1A1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL17366377 0.75 HPGD (0.35) ALDH1A1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL137664 0.73 MAOB (0.70) ALDH1A1MEN1KMT2ACYP1A2MAOB
SCHEMBL2622601 0.73 MAOB (0.70) ALDH1A1MEN1KMT2ACYP1A2MAOB
SCHEMBL2622613 0.73 MAOB (0.70) ALDH1A1MEN1KMT2ACYP1A2MAOB
SCHEMBL17366379 0.73 RELA (0.54) ALDH1A1MEN1KMT2ACYP1A2CYP3A4
SCHEMBL17366361 0.72 HTT (0.36) ALDH1A1MEN1KMT2ACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2960229-B1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC (JP) 2017-02-15 EP disclosed
US-9454091-B2 Hydrazone derivative of triphenylamine and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-27 US disclosed
US-9454091-B2 Hydrazone derivative of triphenylamine and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-27 US disclosed
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-12-31 US disclosed
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2015-12-31 US disclosed
EP-2960229-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER Kyocera Document Solutions Inc. (JP) 2015-12-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150378269-A1 HYDRAZONE DERIVATIVE OF TRIPHENYLAMINE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER NAT1, GSTA1, PKN1 ALDH1A1 49/4885MEN1 90/4885KMT2A 464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.