Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19268056 | 0.90 | HCAR3 (0.44) | ALDH1A1KDM4EPOLBMAPTCYP3A4 | |
| SCHEMBL17376260 | 0.84 | ALDH1A1 (0.40) | ALDH1A1KDM4EPOLBMAPTCYP3A4 | |
| SCHEMBL8564329 | 0.71 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP3A4BLMPMP22 | |
| SCHEMBL30287108 | 0.70 | CYP3A4 (0.45) | ALDH1A1POLBMAPTCYP3A4BLM | |
| SCHEMBL801341 | 0.70 | CYP3A4 (0.45) | ALDH1A1POLBMAPTCYP3A4BLM | |
| SCHEMBL2790806 | 0.70 | PKM (0.67) | ALDH1A1KDM4EPOLBMAPTPKM | |
| SCHEMBL29029068 | 0.69 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBMAPTSMN1; SMN2 | |
| SCHEMBL6512038 | 0.69 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBMAPTLMNA | |
| SCHEMBL19268055 | 0.69 | HCAR3 (0.48) | ALDH1A1KDM4EMAPTCYP3A4LMNA | |
| SCHEMBL12686705 | 0.68 | ALDH1A1 (0.45) | ALDH1A1KDM4EPOLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11261164-B2 | Small molecule agonists of neurotensin receptor 1 | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-03-01 | — | — | US | disclosed |
| US-20200354324-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2020-11-12 | — | — | US | disclosed |
| US-10584103-B2 | Small molecule agonists of neurotensin receptor 1 | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-03-10 | — | — | US | disclosed |
| US-20190023665-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | Sanford Burnham Prebys Medical Discovery Institute | 2019-01-24 | — | — | US | disclosed |
| US-10118902-B2 | Small molecule agonists of neurotensin receptor 1 | Sanford Burnham Prebys Medical Discovery Institute (US) | 2018-11-06 | — | — | US | disclosed |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | Sanford Burnham Prebys Medical Discovery Institute | 2017-08-24 | — | — | US | disclosed |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | Sanford Burnham Prebys Medical Discovery Institute | 2017-08-24 | — | — | US | disclosed |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | Sanford Burnham Prebys Medical Discovery Institute | 2017-08-24 | — | — | US | disclosed |
| EP-3160961-A2 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | Sanford-Burnham Medical Research Institute (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015200534-A2 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015200534-A2 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10584103-B2 | Small molecule agonists of neurotensin receptor 1 | NTSR1, NTSR2, VIPR1 | ALDH1A1 3294/4885KDM4E 4823/4885POLB 4806/4885 |
| US-11261164-B2 | Small molecule agonists of neurotensin receptor 1 | NTSR1, NTSR2, VIPR1 | ALDH1A1 3294/4885KDM4E 4823/4885POLB 4806/4885 |
| US-20170240514-A1 | Small Molecule Agonists of Neurotensin Receptor 1 | NTSR1, NTSR2, VIPR1 | ALDH1A1 3294/4885KDM4E 4823/4885POLB 4806/4885 |
| US-10118902-B2 | Small molecule agonists of neurotensin receptor 1 | NTSR1, NTSR2, VIPR1 | ALDH1A1 3294/4885KDM4E 4823/4885POLB 4806/4885 |
| US-20200354324-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | NTSR1, NTSR2, VIPR1 | ALDH1A1 3294/4885KDM4E 4823/4885POLB 4806/4885 |
| US-20190023665-A1 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 | NTSR1, NTSR2, VIPR1 | ALDH1A1 3294/4885KDM4E 4823/4885POLB 4806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.