Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 2/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 7/20 | 0.60 |
| ▸ | HTR3A | P46098 | 6/20 | 0.60 |
| ▸ | HTR6 | P50406 | 4/20 | 0.60 |
| ▸ | HTR1D | P28221 | 3/20 | 0.60 |
| ▸ | HTR1B | P28222 | 3/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.60 |
| ▸ | HTR3B | O95264 | 3/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.60 |
| ▸ | NCF1 | P14598 | 2/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | MTOR | P42345 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5253513 | 0.99 | HTR5A (0.62) | HTR5AADRB1HTR1AHTR3AHTR6 | |
| SCHEMBL5366747 | 0.89 | HTR1A (0.60) | HTR5AADRB1HTR1AHTR3AHTR6 | |
| Hydrochloric Acid SCHEMBL9639708 | 0.87 | LMNA (0.61) | HTR5AADRB1HTR1AHTR3AHTR6 | |
| SCHEMBL6000211 | 0.84 | HTR1A (0.75) | HTR5AADRB1HTR1AHTR6HTR1D | |
| SCHEMBL27656331 | 0.80 | HTR5A (0.60) | HTR5AHTR1AHTR3AHTR6HTR1D | |
| SCHEMBL8952482 | 0.79 | SLC6A2 (0.56) | HTR5AHTR1AHTR3AHTR6HTR1D | |
| SCHEMBL6959807 | 0.79 | HTR6 (0.72) | HTR5AADRB1HTR1AHTR3AHTR6 | |
| SCHEMBL5252903 | 0.78 | HTR5A (0.68) | HTR5AADRB1HTR1AHTR3AHTR6 | |
| SCHEMBL4546514 | 0.78 | HTR5A (1.00) | HTR5AADRB1HTR1AHTR3AHTR6 | |
| SCHEMBL5372270 | 0.78 | HTR5A (0.68) | HTR5AADRB1HTR1AHTR3AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963680-A | INTERMEDIATES FOR THERAPEUTIC DRUGS | SYNTHELABO (FR) | 1990-10-16 | — | — | US | claimed |
| JP-2073075-A | — | — | None | — | — | JP | disclosed |
| EP-1727794-B1 | NOVEL BENZYL(IDENE)-LACTAM DERIVATIVES | PFIZER PROD INC (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110263484-A1 | SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME | ZYMOGENETICS, INC. | 2011-10-27 | — | — | US | disclosed |
| US-20090286804-A1 | METABOLITES OF 1-[6-(1-ETHYL-1-HYDROXY-PROPYL)-PYRIDIN-3-YL]-3-[2-(4-METHYL-PIPERAZIN-1-YL)-BENZYL]-PYRROLIDIN-2-ONE AS SERATONIN RECEPTOR ANTAGONISTS | PFIZER INC | 2009-11-19 | — | — | US | disclosed |
| US-7479559-B2 | 3-[-2-(Piperazin-1-yl)benzyl]pyrrolidin-2-one derivatives; antidepressants, anxiolytic agents; obsessive compulsive disorder, psychological disorders, phobias; 5-HT1 agonist or antagonists; side effect reduction, in particular cardiac QTc prolongation; hydrogenation | PFIZER INC. (US) | 2009-01-20 | — | — | US | disclosed |
| WO-2008068614-A2 | STEREOSELECTIVE SYNTHESIS OF 1-[6-ETHYL-1,2-DIHYDROXY-PROPYL)-PYRIDIN-3-YL]-3-[2-(4-METHYL-PIPERAZIN-1-YL)-BENZYL]-PYRROLIDIN-2-ONE | PFIZER PRODUCTS INC. (US) | 2008-06-12 | — | — | WO | disclosed |
| EP-1891041-A1 | METABOLITES OF 1- [-6- (1-ETHYL-l-HYDROXY-PROPYL) -PYRIDIN-3-YL]-3- [2- (4-METHYL-PIPERAZIN-I-YL) -BENZYL]-PYRR0LIDIN-2-0NE AS SERATONIN RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2007057742-A2 | NOVEL PIPERAZINONE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007026224-A2 | 5-HT1B ANTAGONIST COMPOSITION FOR DEPRESSION, ANXIETY AND COGNITION | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| US-5162324-A | Naphyl piperazines useful as 5-HT1A receptor ligands | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |
| US-5162321-A | 1-naphthyl piperazines useful as 5-HT1A receptor ligands | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |
| US-5143916-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1992-09-01 | — | — | US | disclosed |
| EP-0483459-A1 | Process for preparation of phosphatidylcholine derivatives | A. Nattermann & Cie. GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| EP-0434561-A2 | 1-Naphthyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-06-26 | — | — | EP | disclosed |
| US-5010079-A | Treatment of psychological disorders | SYNTHELABO (FR) | 1991-04-23 | — | — | US | disclosed |
| US-4983607-A | ANTISEROTONINERGIC ACTIVITY | SYNTHELABO (FR) | 1991-01-08 | — | — | US | disclosed |
| US-4963680-A | INTERMEDIATES FOR THERAPEUTIC DRUGS | SYNTHELABO (FR) | 1990-10-16 | — | — | US | disclosed |
| US-4950670-A | Psychological and cardiovascular disorders | SYNTHELABO (FR) | 1990-08-21 | — | — | US | disclosed |
| JP-H0273075-A | PIPERAZINE DERIVATIVE AND ITS PREPARATION | SYNTHELABO SA | 1990-03-13 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286804-A1 | METABOLITES OF 1-[6-(1-ETHYL-1-HYDROXY-PROPYL)-PYRIDIN-3-YL]-3-[2-(4-METHYL-PIPERAZIN-1-YL)-BENZYL]-PYRROLIDIN-2-ONE AS SERATONIN RECEPTOR ANTAGONISTS | NTSR1, NTSR2, NPSR1 | HTR5A 40/4885ADRB1 95/4885HTR1A 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.