Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 10/20 | 0.50 |
| ▸ | HTR1D | P28221 | 8/20 | 0.50 |
| ▸ | HTR1B | P28222 | 8/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27635274 | 0.91 | HTR6 (0.50) | HTR5AHTR1AHTR1DHTR1BHTR6 | |
| SCHEMBL27836118 | 0.81 | ADRB1 (0.60) | HTR1AHTR1DHTR6HTR3EHTR3B | |
| SCHEMBL1738849 | 0.80 | HTR5A (0.63) | HTR5AHTR1AHTR1DHTR1BHTR6 | |
| Hydrochloric Acid SCHEMBL5253513 | 0.79 | HTR5A (0.62) | HTR5AHTR1AHTR1DHTR1BHTR6 | |
| SCHEMBL27605977 | 0.78 | HTR3E (0.44) | HTR1AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27635277 | 0.78 | HTR6 (0.48) | HTR5AHTR1AHTR1DHTR1BHTR6 | |
| SCHEMBL28754396 | 0.77 | NCF1 (0.55) | HTR1AHTR1DHTR1BHTR6NCF1 | |
| SCHEMBL27674608 | 0.77 | HTR3E (0.43) | HTR1AHTR1DHTR1BHTR3EHTR3B | |
| Tert-Butyl Formate SCHEMBL27656332 | 0.76 | HTR5A (0.73) | HTR5AHTR1AHTR1DHTR1BHTR6 | |
| SCHEMBL31185637 | 0.76 | HTR5A (1.00) | HTR5AHTR1AHTR1DHTR1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100422181-C | [1,8] naphthyridin-2-ones and related compounds for the treatment of schizophrenia | WARNER LAMBERT CO (US) | 2008-10-01 | — | — | CN | disclosed |
| CN-1839134-A | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia | WARNER LAMBERT CO (US) | 2006-09-27 | — | — | CN | disclosed |