Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397933 | 0.80 | ITK (0.41) | HTR6KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL17398026 | 0.78 | ITK (0.48) | HTR6KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL17398060 | 0.78 | AURKA (0.46) | — | |
| SCHEMBL17397982 | 0.76 | ALDH1A1 (0.43) | HTR6KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL17398031 | 0.75 | KDM4E (0.44) | KDM4EALDH1A1PKMSMN1; SMN2HTT | |
| SCHEMBL17398079 | 0.73 | KMT2A (0.39) | HTR6KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL17398012 | 0.73 | ALDH1A1 (0.48) | HTR6ALDH1A1PKMSMN1; SMN2HTT | |
| SCHEMBL17398018 | 0.72 | MAPT (0.44) | KDM4EALDH1A1SMN1; SMN2GAA | |
| SCHEMBL17398074 | 0.72 | WDR5 (0.43) | HTR6GAAKMT2A | |
| SCHEMBL17397958 | 0.72 | ITK (0.46) | HTR6KDM4EALDH1A1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |