Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398074 | 0.85 | WDR5 (0.43) | ITKHTR6PAK4KMT2ALMNA | |
| SCHEMBL17398031 | 0.79 | KDM4E (0.44) | KMT2ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL17398025 | 0.79 | ITK (0.63) | ITKHTR6JAK2JAK3PAK4 | |
| SCHEMBL17397937 | 0.78 | HTR6 (0.43) | HTR6KMT2AL3MBTL1HTTALDH1A1 | |
| SCHEMBL17397982 | 0.77 | ALDH1A1 (0.43) | HTR6KMT2ALMNAL3MBTL1HTT | |
| SCHEMBL17398060 | 0.74 | AURKA (0.46) | JAK2JAK3PAK4SRCBTK | |
| SCHEMBL17397958 | 0.73 | ITK (0.46) | ITKHTR6KMT2ALMNAL3MBTL1 | |
| SCHEMBL17398079 | 0.71 | KMT2A (0.39) | HTR6KMT2ALMNAL3MBTL1HTT | |
| SCHEMBL17398012 | 0.71 | ALDH1A1 (0.48) | HTR6KMT2ALMNAL3MBTL1HTT | |
| SCHEMBL17398018 | 0.71 | MAPT (0.44) | PAK4LMNAALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |