SCHEMBL17427478

SCHEMBL17427478

Cn1cnnc1NC(=O)c1cn(C)c(=O)n(-c2cccc(F)c2F)c1=O

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
MAP3K5 Q99683 8/20 0.35
MET P08581 6/20 0.35
AXL P30530 3/20 0.35
CBLB Q13191 1/20 0.35
CHRM4 P08173 1/20 0.34
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17427479 0.85 POLB (0.47) LMNAGAAMETAXLKMT2A
SCHEMBL17427487 0.84 RIPK1 (0.35) LMNAGAAMAP3K5METCHRM4
SCHEMBL16022018 0.84 AXL (0.37) LMNAGAAMETAXL
SCHEMBL17427477 0.81 MET (0.38) LMNAMAP3K5METAXLKMT2A
SCHEMBL16022005 0.69 POLB (0.44) LMNAMETKMT2A
SCHEMBL17427481 0.66 HPGD (0.53) LMNAGAAMETAXL
SCHEMBL17427486 0.65 CTDSP1 (0.39) KMT2A
SCHEMBL17427475 0.65 TYRO3 (0.41) METAXLKMT2A
SCHEMBL16022003 0.64 HCAR1 (0.40) LMNAGAAKMT2A
SCHEMBL16022024 0.64 SMN1; SMN2 (0.40) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160009693-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2016-01-14 US disclosed
US-20160009693-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2016-01-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160009693-A1 HERBICIDAL COMPOUNDS DDT, HAX1, CYP4X1 LMNA 3606/4885GAA 474/4885MAP3K5 4039/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.