SCHEMBL17440403

SCHEMBL17440403

Clc1cnc(Oc2ccccc2)nc1Oc1ccccn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 2/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
NPC1 O15118 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
GAA P10253 1/20 0.43
RAB9A P51151 1/20 0.43
SCN9A Q15858 1/20 0.40
ALDH1A1 P00352 10/20 0.40
HTT P42858 2/20 0.40
CYP1A2 P05177 7/20 0.39
CYP2C19 P33261 4/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
CYP2D6 P10635 1/20 0.38
CYP3A4 P08684 4/20 0.38
HSD17B10 Q99714 2/20 0.38
HIF1A Q16665 1/20 0.38
MAPK1 P28482 2/20 0.38
TSHR P16473 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29610302 0.74 LOXL2 (0.52) NPC1SMN1; SMN2RAB9AALDH1A1HTT
SCHEMBL147539 0.74 LOXL2 (0.52) NPC1SMN1; SMN2RAB9AALDH1A1HTT
SCHEMBL8510667 0.72 LTA4H (0.50) NPC1SMN1; SMN2RAB9AALDH1A1HTT
SCHEMBL5443693 0.72 LTA4H (0.50) NPC1SMN1; SMN2RAB9AALDH1A1HTT
SCHEMBL29596360 0.72 PIN1 (0.64) PIN1MEN1KMT2ANPC1SMN1; SMN2
SCHEMBL22895754 0.72 PIN1 (0.64) PIN1MEN1KMT2ANPC1SMN1; SMN2
SCHEMBL17440404 0.71 ELANE (0.40) MEN1KMT2ANPC1SMN1; SMN2GAA
Methyl Alcohol SCHEMBL11157137 0.70 GPR39 (0.51) NPC1SMN1; SMN2RAB9AALDH1A1HTT
SCHEMBL15346818 0.69 KDM4E (0.46) PIN1NPC1SMN1; SMN2SCN9AALDH1A1
SCHEMBL22911840 0.69 BCL6 (0.49) PIN1MEN1KMT2ANPC1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3169676-A1 BIS(ARYL)CATECHOL DERIVATIVES AS HERBICIDES E. I. du Pont de Nemours and Company (US) 2017-05-24 EP disclosed
WO-2016010731-A1 BIS(ARYL)CATECHOL DERIVATIVES AS HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2016-01-21 WO disclosed