Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | PANK3 | Q9H999 | 4/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17460668 | 0.87 | HPGDS (0.59) | HPGDSNPC1SCN4ARAB9ASMN1; SMN2 | |
| SCHEMBL27971152 | 0.84 | CTSS (0.43) | HPGDSEGFRERBB2PRKDC | |
| SCHEMBL10199417 | 0.81 | NPC1 (0.44) | NPC1SCN4ARAB9ASMN1; SMN2MET | |
| SCHEMBL15125079 | 0.78 | HPGDS (0.51) | HPGDS | |
| SCHEMBL10262257 | 0.76 | CYP1A2 (0.53) | NPC1SCN4ARAB9ASMN1; SMN2PSMB5 | |
| SCHEMBL15701603 | 0.75 | SLC6A2 (0.41) | CYP19A1IDH1 | |
| SCHEMBL12850742 | 0.75 | HPGDS (0.47) | HPGDSCDC7HTT | |
| SCHEMBL19514095 | 0.75 | NPC1 (0.40) | NPC1SCN4ARAB9ASMN1; SMN2MET | |
| SCHEMBL1894034 | 0.75 | EGFR (0.53) | HPGDSSMN1; SMN2EGFRATMCDC7 | |
| SCHEMBL12850560 | 0.75 | HPGDS (0.47) | HPGDSCDC7HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-11535643-B2 | Macrolides with modified desosamine sugars and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-12-27 | — | — | US | disclosed |
| US-10913764-B2 | Macrolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200377542-A1 | MACROLIDES WITH MODIFIED DESOSAMINE SUGARS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-12-03 | — | — | US | disclosed |
| US-20200361980-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-11-19 | — | — | US | disclosed |
| US-10640528-B2 | Macrolides with modified desosamine sugars and uses thereof | PRESIDENT AND FELLOWS OF HAVARD COLLEGE (US) | 2020-05-05 | — | — | US | disclosed |
| US-10633407-B2 | 14-membered ketolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-04-28 | — | — | US | disclosed |
| US-10227340-B2 | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180072712-A1 | THIAZOLYL- OR THIADIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-15 | — | — | US | disclosed |
| US-20180072712-A1 | THIAZOLYL- OR THIADIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-15 | — | — | US | disclosed |
| US-20180066008-A1 | MACROLIDES WITH MODIFIED DESOSAMINE SUGARS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-03-08 | — | — | US | disclosed |
| US-20170305953-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-10-26 | — | — | US | disclosed |
| US-9242976-B2 | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180066008-A1 | MACROLIDES WITH MODIFIED DESOSAMINE SUGARS AND USES THEREOF | FUT6, MGAM, B3GNT2 | HPGDS 1346/4885NPC1 383/4885SCN4A 3415/4885 |
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | HPGDS 1575/4885NPC1 2447/4885SCN4A 2690/4885 |
| US-20180072712-A1 | THIAZOLYL- OR THIADIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS | IRAK4, IRAK1, IRAK3 | HPGDS 3675/4885NPC1 2588/4885SCN4A 1415/4885 |
| US-11535643-B2 | Macrolides with modified desosamine sugars and uses thereof | FUT6, MGAM, B3GNT2 | HPGDS 1346/4885NPC1 383/4885SCN4A 3415/4885 |
| US-20170305953-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP51A1, HSD17B7, CYP11B1 | HPGDS 159/4885NPC1 1344/4885SCN4A 3349/4885 |
| US-10227340-B2 | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors | IRAK4, IRAK1, IRAK3 | HPGDS 3675/4885NPC1 2588/4885SCN4A 1415/4885 |
| US-20200377542-A1 | MACROLIDES WITH MODIFIED DESOSAMINE SUGARS AND USES THEREOF | FUT6, MGAM, B3GNT2 | HPGDS 1346/4885NPC1 383/4885SCN4A 3415/4885 |
| US-10913764-B2 | Macrolides and methods of their preparation and use | CYP11B2, ERG28, DHCR7 | HPGDS 1660/4885NPC1 141/4885SCN4A 4287/4885 |
| US-10640528-B2 | Macrolides with modified desosamine sugars and uses thereof | FUT6, MGAM, B3GNT2 | HPGDS 1346/4885NPC1 383/4885SCN4A 3415/4885 |
| US-10633407-B2 | 14-membered ketolides and methods of their preparation and use | CYP51A1, HSD17B7, CYP11B1 | HPGDS 159/4885NPC1 1344/4885SCN4A 3349/4885 |
| US-20200361980-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP51A1, KHK, HSD17B7 | HPGDS 101/4885NPC1 1047/4885SCN4A 3492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.