SCHEMBL17468798

SCHEMBL17468798

C=COC(=O)N1Cc2ccccc2OC(c2ccc(F)cc2F)C1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
TAS1R2 Q8TE23 1/20 0.38
CHRM3 P20309 2/20 0.36
NTRK1 P04629 1/20 0.35
PDE4B Q07343 1/20 0.34
PDE4D Q08499 1/20 0.34
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
AHR P35869 1/20 0.32
ABHD6 Q9BV23 1/20 0.32
DPP8 Q6V1X1 2/20 0.32
DPP9 Q86TI2 1/20 0.32
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
MAOB P27338 3/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17468801 0.90 POLB (0.36) TAS1R3TAS1R1TAS1R2ALDH1A1SMN1; SMN2
SCHEMBL17469002 0.90 ABHD6 (0.36) ALDH1A1HPGDAHRABHD6NPC1
SCHEMBL17468800 0.87 ALDH1A1 (0.35) NTRK1PDE4BALDH1A1HPGDSMN1; SMN2
SCHEMBL17469009 0.81 ABHD6 (0.34) TAS1R3TAS1R1TAS1R2ALDH1A1HPGD
SCHEMBL17468913 0.81 CYP19A1 (0.38) ALDH1A1HPGDABHD6NPC1RAB9A
SCHEMBL17469136 0.78 SLC6A2 (0.32) DPP8DPP9NPC1RAB9ADPP7
SCHEMBL17459385 0.77 TAS1R3 (0.38) TAS1R3TAS1R1TAS1R2NAMPT
SCHEMBL17469012 0.77 NAMPT (0.41) ABHD6NAMPT
SCHEMBL17459478 0.76 SLC22A12 (0.34) ALDH1A1
SCHEMBL17468799 0.76 ALDH1A1 (0.40) ALDH1A1HPGDSMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016012333-A1 PESTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2016-01-28 WO disclosed