Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 3/20 | 0.37 |
| ▸ | KDM4B | O94953 | 3/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.37 |
| ▸ | KDM5C | P41229 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 2/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3353320 | 0.98 | KDM4A (0.36) | KDM4AKDM4BKDM5BKDM5CCDK5 | |
| Formic Acid SCHEMBL31745120 | 0.89 | GDA (0.38) | KDM4AKDM4BKDM5BKDM5CCDK5 | |
| SCHEMBL1056425 | 0.74 | KDM4A (0.37) | KDM4AKDM4BKDM5BKDM5CCDK5 | |
| SCHEMBL1374153 | 0.74 | KDM4A (0.37) | KDM4AKDM4BKDM5BKDM5CCDK5 | |
| SCHEMBL31485777 | 0.74 | KDM4A (0.37) | KDM4AKDM4BKDM5BKDM5CCDK5 | |
| SCHEMBL29696567 | 0.71 | GDA (0.39) | KDM4AKDM4BKDM5BKDM5CGDA | |
| SCHEMBL60386 | 0.68 | KDM4A (0.33) | KDM4AKDM4BKDM5BKDM5CNOS3 | |
| SCHEMBL1800839 | 0.68 | CDK5 (0.42) | CDK5CDK5R1MMP12PI4KBKDM4E | |
| SCHEMBL28369641 | 0.65 | GDA (0.37) | GDAPDPK1KDM4EMAPT | |
| SCHEMBL4838539 | 0.65 | MMP12 (0.39) | CDK5CDK5R1MMP12NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117865965-B | Pyrrolopyrimidine-4-amine and pyrazolopyrimidine-4-amine derivatives, preparation method and application thereof | 贵州省天然产物研究中心 | 2024-06-28 | — | — | CN | claimed |
| CN-117865965-A | Pyrrolopyrimidine-4-amine and pyrazolopyrimidine-4-amine derivatives, preparation method and application thereof | 贵州省天然产物研究中心 | 2024-04-12 | — | — | CN | claimed |
| CN-111454261-A | Synthesis method of 4-chloro-pyrrolopyrimidine compound | 南京普锐达医药科技有限公司 | 2020-07-28 | — | — | CN | claimed |
| CN-107803189-B | Chromatography medium using 4-amino pyrrolo [3,2-D ] pyrimidine as functional ligand | 苏州博进生物技术有限公司 | 2020-07-14 | — | — | CN | claimed |
| WO-1997049706-A1 | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF | NOVARTIS AG (CH) | 1997-12-31 | — | — | WO | claimed |
| CN-121758450-A | Preparation method of pyrrolopyrimidine-4-amine derivative | 山东轩硕医药科技有限公司 | 2026-03-31 | — | — | CN | disclosed |
| CN-121758450-A | Preparation method of pyrrolopyrimidine-4-amine derivative | 山东轩硕医药科技有限公司 | 2026-03-31 | — | — | CN | disclosed |
| US-20250382305-A1 | COMPOUNDS FOR TREATING SPINOCEREBELLAR ATAXIA TYPE 3 | PTC THERAPEUTICS INC (US) | 2025-12-18 | — | — | US | disclosed |
| CN-119528862-A | Dehydrocostuslactone derivative and preparation method and medical application thereof | 昆明理工大学 | 2025-02-28 | — | — | CN | disclosed |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | BUCK INST RES AGING (US) | 2024-07-04 | — | — | US | disclosed |
| CN-117865965-B | Pyrrolopyrimidine-4-amine and pyrazolopyrimidine-4-amine derivatives, preparation method and application thereof | 贵州省天然产物研究中心 | 2024-06-28 | — | — | CN | disclosed |
| CN-117865965-B | Pyrrolopyrimidine-4-amine and pyrazolopyrimidine-4-amine derivatives, preparation method and application thereof | 贵州省天然产物研究中心 | 2024-06-28 | — | — | CN | disclosed |
| US-6020492-A | Deazapurine derivatives; a new class of CRF1 specific ligands | NEUROGEN CORPORATION (US) | 2000-02-01 | — | — | US | disclosed |
| US-5985848-A | EFFECTIVE INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE AND/OR NUCLEOSIDE HYDROLASES; TREATMENT AND/OR PROPHYLAXIS OF A PROTOZOAN INFECTION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0770080-B1 | NOVEL DEAZAPURINE DERIVATIVES; A NEW CLASS OF CRF1 SPECIFIC LIGANDS | NEUROGEN CORP (US) | 1999-07-14 | — | — | EP | disclosed |
| EP-0674641-B1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5644057-A | Deazapurine derivatives; a new class of CRF1 specific ligands | NEUROGEN CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0729758-A2 | Pyrazolopyrimidines and pyrrolopyrimidines for treatment of neuronal and other disorders | PFIZER INC. (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0674641-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013676-A1 | PYRROLOPYRIMIDINES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250382305-A1 | COMPOUNDS FOR TREATING SPINOCEREBELLAR ATAXIA TYPE 3 | ATXN2, SMN1; SMN2, ATXN10 | KDM4A 3102/4885KDM4B 3076/4885KDM5B 3239/4885 |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | DAGLA, DAGLB, MGLL | KDM4A 2568/4885KDM4B 2236/4885KDM5B 2444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.