Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16057026 | 1.00 | GPR55 (0.53) | GPR55SIGMAR1MEN1ALDH1A1KMT2A | |
| SCHEMBL810837 | 0.78 | HTR2A (0.51) | SIGMAR1MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7358605 | 0.78 | ADAM17 (0.52) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL7878258 | 0.78 | ADAM17 (0.52) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL7872221 | 0.78 | ADAM17 (0.52) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL7879791 | 0.75 | ADAM17 (0.52) | ADAM17MMP1MMP9MMP13 | |
| SCHEMBL9303072 | 0.74 | ALDH1A1 (0.73) | GPR55MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL31630110 | 0.74 | MMP2 (0.49) | GPR55MEN1ALDH1A1KMT2ACA1 | |
| SCHEMBL31630207 | 0.74 | MMP2 (0.49) | GPR55MEN1ALDH1A1KMT2ACA1 | |
| SCHEMBL7379373 | 0.71 | MMP1 (0.81) | ALDH1A1TSHRTAS2R14MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3998260-B1 | SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3998260-A1 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| EP-3660013-A1 | SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2020-06-03 | — | — | EP | disclosed |
| US-10183021-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170137439-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170137439-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170136019-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170136019-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-9586937-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9586937-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160375022-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-12-29 | — | — | US | disclosed |
| US-20160347738-A1 | sGC STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2016-12-01 | — | — | US | disclosed |
| US-9481689-B2 | sGC stimulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20160031903-A1 | sGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137439-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | GPR55 594/4885SIGMAR1 1325/4885MEN1 2447/4885 |
| US-20160347738-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | GPR55 594/4885SIGMAR1 1325/4885MEN1 2447/4885 |
| US-10183021-B2 | sGC stimulators | PTGIS, CGAS, GUCY1A1 | GPR55 594/4885SIGMAR1 1325/4885MEN1 2447/4885 |
| US-20170136019-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | GPR55 594/4885SIGMAR1 1325/4885MEN1 2447/4885 |
| US-20160375022-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | GPR55 594/4885SIGMAR1 1325/4885MEN1 2447/4885 |
| US-20160031903-A1 | sGC STIMULATORS | PTGIS, CGAS, GUCY1A1 | GPR55 594/4885SIGMAR1 1325/4885MEN1 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.