Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123636 | 0.87 | NQO1 (0.40) | SMN1; SMN2NQO1HPGDALOX5CYP1A2 | |
| SCHEMBL2540847 | 0.83 | ALDH1A1 (0.35) | SMN1; SMN2SRCALDH1A1KMT2ATSHR | |
| SCHEMBL29141709 | 0.80 | TDP1 (0.46) | SMN1; SMN2NQO1HPGDALOX5CYP1A2 | |
| SCHEMBL4898922 | 0.79 | ALDH1A1 (0.55) | SMN1; SMN2NQO1HPGDLMNAALDH1A1 | |
| SCHEMBL17485847 | 0.79 | ALDH1A1 (0.51) | SMN1; SMN2NQO1HPGDALOX5CYP1A2 | |
| SCHEMBL2544210 | 0.78 | ALDH1A1 (0.52) | SMN1; SMN2HPGDCYP1A2SRCALDH1A1 | |
| SCHEMBL19248471 | 0.77 | CA2 (0.38) | SMN1; SMN2SRCKMT2AMAPTNPC1 | |
| SCHEMBL17485838 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDALOX5CYP1A2LMNA | |
| SCHEMBL16358205 | 0.75 | ALOX5 (0.53) | SMN1; SMN2HPGDALOX5PKMALDH1A1 | |
| SCHEMBL18460760 | 0.75 | SMN1; SMN2 (0.35) | SMN1; SMN2NQO1HPGDALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170029395-A1 | SYNTHESIS OF DERIVATIVES OF DICARBAMATES FROM REDUCTION PRODUCTS OF 2-HYDROXYMETHYL-5-FURUFURAL (HMF) | ARCHER DANIELS MIDLAND COMPANY | 2017-02-02 | — | — | US | disclosed |
| US-9487537-B2 | Synthesis of isohexide dicarbamates and derivatives thereof | ARCHER DANIELS MIDLAND CO. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20160031842-A1 | SYNTHESIS OF ISOHEXIDE DICARBAMATES AND DERIVATIVES THEREOF | ARCHER DANIELS MIDLAND CO (US) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031842-A1 | SYNTHESIS OF ISOHEXIDE DICARBAMATES AND DERIVATIVES THEREOF | DCK, MCCC2, PRKAA1 | SMN1; SMN2 4288/4885NQO1 3325/4885HPGD 344/4885 |
| US-20170029395-A1 | SYNTHESIS OF DERIVATIVES OF DICARBAMATES FROM REDUCTION PRODUCTS OF 2-HYDROXYMETHYL-5-FURUFURAL (HMF) | MGMT, TKFC, DMPK | SMN1; SMN2 3890/4885NQO1 1735/4885HPGD 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.