Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747920 | 0.81 | MAOA (0.54) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1748981 | 0.78 | KDM4E (0.68) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL141303 | 0.76 | MAPT (0.59) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30448936 | 0.76 | MAPT (0.59) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3207284 | 0.76 | ELANE (0.58) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29746267 | 0.76 | KDM4E (1.00) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL7004578 | 0.76 | KDM4E (1.00) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL20660884 | 0.74 | ALDH1A1 (0.56) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26613484 | 0.74 | NPC1 (0.63) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL2240300 | 0.74 | RAB9A (0.64) | MAPTALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| EP-2057148-B1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM SPA (IT) | 2009-12-30 | — | — | EP | disclosed |
| EP-2057148-B1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM SPA (IT) | 2009-12-30 | — | — | EP | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| EP-2057148-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | Rottapharm S.p.A. (IT) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008014815-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008014815-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | NOS2, NOS3, NOS1 | MAPT 3130/4885ALDH1A1 1153/4885KDM4E 2821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.