Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 13/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | IL6 | P05231 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17488336 | 0.89 | SCN9A (0.42) | — | |
| SCHEMBL17488105 | 0.86 | RAB9A (0.41) | P2RX3IL6TLR7CYP3A4CYP1A2 | |
| SCHEMBL17487676 | 0.84 | CYP3A4 (0.36) | P2RX3IL6TLR7CYP3A4 | |
| SCHEMBL17488334 | 0.82 | FABP4 (0.34) | PIM1FABP4 | |
| SCHEMBL18965979 | 0.82 | CYP3A4 (0.43) | P2RX3CYP3A4 | |
| SCHEMBL17488013 | 0.81 | RAB9A (0.39) | P2RX3IL6TLR7CYP1A2CYP2D6 | |
| SCHEMBL17488308 | 0.79 | GRM4 (0.40) | GRM4P2RX3PIM1CYP1A2CYP2D6 | |
| SCHEMBL17488159 | 0.79 | RAB9A (0.41) | P2RX3IL6TLR7 | |
| SCHEMBL17488011 | 0.79 | RIPK1 (0.37) | CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17487717 | 0.78 | RAB9A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016421-A1 | 2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS | INSTITUT PASTEUR KOREA (KR) | 2016-02-04 | — | — | WO | disclosed |