Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 8/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.33 |
| ▸ | RECQL | P46063 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21485265 | 0.79 | ALDH1A1 (0.50) | HPGDKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL19559077 | 0.73 | MEN1 (0.41) | HPGDALOX15KDM4ECYP1A2CYP3A4 | |
| SCHEMBL30444626 | 0.73 | KMT2A (0.46) | HPGDKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL19557283 | 0.72 | CYP1A2 (0.39) | HPGDCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL17504839 | 0.72 | GRM2 (0.42) | KMT2A | |
| SCHEMBL29509074 | 0.72 | GRM2 (0.42) | KMT2A | |
| SCHEMBL19557287 | 0.69 | KDM4E (0.36) | HPGDKDM4ECYP1A2MEN1KMT2A | |
| SCHEMBL29509124 | 0.69 | MAPT (0.37) | HPGDKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL17504860 | 0.69 | MAPT (0.37) | HPGDKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL28176244 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | disclosed |
| CN-111253424-B | Silylation of aromatic heterocycles over earth-rich transition metal-free catalysts | 加州理工学院 | 2023-06-20 | — | — | CN | disclosed |
| EP-3705482-B1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INST OF TECHN (US) | 2023-02-22 | — | — | EP | disclosed |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-06-16 | — | — | US | disclosed |
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210047348-A1 | Silylated Derivatives Of Aromatic Heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2021-02-18 | — | — | US | disclosed |
| EP-3536694-B1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INST OF TECHN (US) | 2020-12-02 | — | — | EP | disclosed |
| EP-3705482-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | California Institute of Technology (US) | 2020-09-09 | — | — | EP | disclosed |
| CN-111253424-A | Silylation of aromatic heterocycles by earth-rich transition metal-free catalysts | 加州理工学院 | 2020-06-09 | — | — | CN | disclosed |
| CN-107108662-B9 | Silylation of aromatic heterocycles by earth-rich transition metal-free catalysts | 加州理工学院 | 2020-05-15 | — | — | CN | disclosed |
| EP-3177630-B1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INST OF TECHN (US) | 2019-10-23 | — | — | EP | disclosed |
| EP-3536694-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | California Institute of Technology (US) | 2019-09-11 | — | — | EP | disclosed |
| US-20190048030-A1 | SILYLATED DERIVATIVES OF AROMATIC HETEROCYCLES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-02-14 | — | — | US | disclosed |
| US-10125153-B2 | Preparation of silylamines by the dehydrogeative coupling of N—H and Si—H bonds | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-11-13 | — | — | US | disclosed |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2018-03-01 | — | — | US | disclosed |
| US-9809607-B2 | Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-07 | — | — | US | disclosed |
| EP-3177630-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | California Institute of Technology (US) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016022624-A9 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-03-10 | — | — | WO | disclosed |
| US-20160046653-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2016-02-18 | — | — | US | disclosed |
| WO-2016022624-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | HPGD 1205/4885ALOX15 4247/4885KDM4E 893/4885 |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | TEC, AURKA, TYR | HPGD 2419/4885ALOX15 4401/4885KDM4E 633/4885 |
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | HPGD 1205/4885ALOX15 4247/4885KDM4E 893/4885 |
| US-10125153-B2 | Preparation of silylamines by the dehydrogeative coupling of N—H and Si—H bonds | SAMHD1, HRH3, DOHH | HPGD 406/4885ALOX15 3535/4885KDM4E 1656/4885 |
| US-20210047348-A1 | Silylated Derivatives Of Aromatic Heterocycles | KCNH1, KCNH3, HNRNPH3 | HPGD 1205/4885ALOX15 4247/4885KDM4E 893/4885 |
| US-20160046653-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | TEC, AURKA, KARS1 | HPGD 2431/4885ALOX15 4291/4885KDM4E 468/4885 |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | KCNH1, KCNH3, HNRNPH3 | HPGD 1205/4885ALOX15 4247/4885KDM4E 893/4885 |
| US-20190048030-A1 | SILYLATED DERIVATIVES OF AROMATIC HETEROCYCLES | HNRNPH3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SBK3 | HPGD 1189/4885ALOX15 4523/4885KDM4E 1958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.