Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 6/20 | 0.38 |
| ▸ | THRB | P10828 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24508439 | 0.79 | CA2 (0.52) | MEN1KMT2AALDH1A1MAPTCA2 | |
| SCHEMBL19559092 | 0.76 | MAPT (0.46) | MEN1KMT2AALDH1A1MAPTRECQL | |
| SCHEMBL17504853 | 0.73 | HPGD (0.38) | MEN1KMT2AALDH1A1MAPTCA2 | |
| SCHEMBL18685613 | 0.73 | KMT2A (0.46) | MEN1KMT2AALDH1A1MAPTRECQL | |
| SCHEMBL19559087 | 0.72 | HTR6 (0.41) | MEN1KMT2AALDH1A1MAPTRECQL | |
| SCHEMBL17504841 | 0.68 | PRKCI (0.50) | LMNATP53 | |
| SCHEMBL19559091 | 0.68 | RAPGEF4 (0.37) | ALDH1A1MAPTHPGDKDM4ELMNA | |
| SCHEMBL4194127 | 0.67 | LMNA (0.50) | MAPTCA2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL29871774 | 0.67 | LMNA (0.50) | MAPTCA2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL20739962 | 0.67 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | disclosed |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-06-16 | — | — | US | disclosed |
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210047348-A1 | Silylated Derivatives Of Aromatic Heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2021-02-18 | — | — | US | disclosed |
| US-10919917-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-02-16 | — | — | US | disclosed |
| US-10513531-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-12-24 | — | — | US | disclosed |
| US-20190048030-A1 | SILYLATED DERIVATIVES OF AROMATIC HETEROCYCLES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-02-14 | — | — | US | disclosed |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2018-03-01 | — | — | US | disclosed |
| US-9809607-B2 | Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | MEN1 3045/4885KMT2A 654/4885ALDH1A1 1686/4885 |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | TEC, AURKA, TYR | MEN1 806/4885KMT2A 384/4885ALDH1A1 1843/4885 |
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | MEN1 3045/4885KMT2A 654/4885ALDH1A1 1686/4885 |
| US-10919917-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | MEN1 2882/4885KMT2A 566/4885ALDH1A1 1869/4885 |
| US-20210047348-A1 | Silylated Derivatives Of Aromatic Heterocycles | KCNH1, KCNH3, HNRNPH3 | MEN1 3045/4885KMT2A 654/4885ALDH1A1 1686/4885 |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | KCNH1, KCNH3, HNRNPH3 | MEN1 3045/4885KMT2A 654/4885ALDH1A1 1686/4885 |
| US-10513531-B2 | Silylated derivatives of aromatic heterocycles | HNRNPH3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SBK3 | MEN1 1714/4885KMT2A 825/4885ALDH1A1 1755/4885 |
| US-20190048030-A1 | SILYLATED DERIVATIVES OF AROMATIC HETEROCYCLES | HNRNPH3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SBK3 | MEN1 1714/4885KMT2A 825/4885ALDH1A1 1755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.