Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19399634 | 0.82 | PRKAG1 (0.42) | ALDH1A1HSD17B10KDM4EGAAMAOA | |
| SCHEMBL10284441 | 0.76 | GAA (0.54) | ALDH1A1HSD17B10KDM4EGAACYP1A2 | |
| SCHEMBL19377819 | 0.71 | ALDH1A1 (0.55) | MAPTALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL15844358 | 0.70 | RAD52 (0.43) | MAPTALDH1A1HSD17B10KDM4EMEN1 | |
| SCHEMBL19115947 | 0.70 | MAPT (0.61) | MAPTALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL24553685 | 0.69 | CSNK2A1 (0.34) | ALDH1A1HSD17B10KDM4EGAAEGFR | |
| SCHEMBL29732979 | 0.69 | CSNK2A1 (0.34) | ALDH1A1HSD17B10KDM4EGAAEGFR | |
| SCHEMBL23709934 | 0.68 | RHEB (0.63) | MAPTALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL6345103 | 0.68 | ALDH1A1 (0.97) | MAPTALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL16134498 | 0.67 | L3MBTL1 (0.44) | ALDH1A1HSD17B10KDM4EGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | UNIVERSITY OF WASHINGTON (US) | 2021-02-09 | — | — | US | disclosed |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | AARS1, MTR, GARS1 | MAPT 3016/4885ALDH1A1 2330/4885SMN1; SMN2 1086/4885 |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | AARS1, MTR, GARS1 | MAPT 3016/4885ALDH1A1 2330/4885SMN1; SMN2 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.