Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 4/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17513286 | 0.82 | MAPT (0.50) | HRH4MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL31715979 | 0.79 | PRKAG1 (0.43) | PRKAG1PRKAA2PRKAB1PRKAA1NPC1 | |
| SCHEMBL10284441 | 0.77 | GAA (0.54) | HRH4GRIN1KDM4EGRIN2DGRIN3B | |
| SCHEMBL3100859 | 0.75 | RAB9A (0.52) | PRKAG1PRKAA2PRKAB1PRKAA1NPC1 | |
| SCHEMBL31716315 | 0.74 | PRKAG1 (0.72) | PRKAG1PRKAA2PRKAB1PRKAA1PRKCZ | |
| SCHEMBL15844358 | 0.74 | RAD52 (0.43) | PRKAG1PRKAA2PRKAB1PRKAA1GRIN1 | |
| Hydrochloric Acid SCHEMBL5111382 | 0.74 | RAB9A (0.51) | PRKAG1PRKAA2PRKAB1PRKAA1NPC1 | |
| SCHEMBL24553685 | 0.73 | CSNK2A1 (0.34) | GRIN1KDM4EGRIN2DGRIN3BALDH1A1 | |
| SCHEMBL29732979 | 0.73 | CSNK2A1 (0.34) | GRIN1KDM4EGRIN2DGRIN3BALDH1A1 | |
| SCHEMBL19377819 | 0.73 | ALDH1A1 (0.55) | NPC1RAB9AKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | UNIVERSITY OF WASHINGTON (US) | 2021-02-09 | — | — | US | disclosed |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | AARS1, MTR, GARS1 | PRKAG1 1504/4885PRKAA2 803/4885PRKAB1 1806/4885 |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | AARS1, MTR, GARS1 | PRKAG1 1504/4885PRKAA2 803/4885PRKAB1 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.