SCHEMBL17514930

SCHEMBL17514930

COc1[c]cccc1-c1ccc(F)cc1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 6/20 0.37
F2RL3 Q96RI0 1/20 0.35
ALPL P05186 1/20 0.34
AMY1A P0DUB6 1/20 0.33
CHRM3 P20309 1/20 0.33
IDO1 P14902 2/20 0.32
AGXT P21549 2/20 0.32
GPR3 P46089 1/20 0.32
ALOX5AP P20292 2/20 0.32
FEN1 P39748 2/20 0.32
TRPA1 O75762 1/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
HSD17B10 Q99714 1/20 0.31
PDE3B Q13370 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17514527 0.87 PTPN1 (0.36) MAPK14MEN1NPC1RAB9AKMT2A
SCHEMBL17514951 0.86 S1PR1 (0.38) MAPK14GPR3PDE3BPDE3A
SCHEMBL17514487 0.84 HSD11B1 (0.36) AMY1AGPR3KMT2A
SCHEMBL17514655 0.84 HSD11B1 (0.41) MAPK14AMY1A
SCHEMBL17514690 0.84 AMY1A (0.34) AMY1AGPR3NPSR1HSD17B10
SCHEMBL2086754 0.83 RAB9A (0.36) F2RL3NPC1ALDH1A1HPGDRAB9A
SCHEMBL17514960 0.83 HTR7 (0.35) HPGD
SCHEMBL17514584 0.82 TUBB4A (0.33)
SCHEMBL17514995 0.81 HTR1A (0.37) AMY1A
SCHEMBL17514751 0.81 AMY1A (0.32) AMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016026830-A1 NOVEL FUNGICIDAL PYRAZOLE DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-02-25 WO disclosed