Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 18/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14264462 | 0.81 | RAB9A (0.49) | CFTRHPGDRAB9ALIMK1TP53 | |
| SCHEMBL165773 | 0.79 | ADORA3 (0.61) | MAPT | |
| SCHEMBL27653923 | 0.78 | ALDH1A1 (0.64) | MAPT | |
| SCHEMBL4880488 | 0.78 | FBP1 (0.57) | — | |
| SCHEMBL257616 | 0.76 | ADORA3 (0.64) | HPGDRAB9AMAPT | |
| SCHEMBL10092883 | 0.76 | RORB (0.67) | — | |
| SCHEMBL18411276 | 0.75 | CDK4 (0.55) | HPGDRAB9ALIMK1TP53MAPT | |
| SCHEMBL2762916 | 0.72 | ALDH1A1 (0.64) | MAPT | |
| SCHEMBL7816239 | 0.72 | SRD5A2 (0.81) | HPGDRAB9AMAPT | |
| SCHEMBL976273 | 0.71 | CDC7 (0.60) | CFTRHPGDRAB9ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012027965-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |