SCHEMBL1756154

SCHEMBL1756154

NCOB(O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
TRPM2 O94759 1/20 0.47
ALDH1A1 P00352 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
THRB P10828 1/20 0.47
HPGD P15428 1/20 0.47
ALOX15 P16050 1/20 0.47
TSHR P16473 1/20 0.47
ALOX12 P18054 1/20 0.47
MAPK1 P28482 1/20 0.47
KMT2A Q03164 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
TRPV6 Q9H1D0 4/20 0.44
ORAI1 Q96D31 3/20 0.44
ORAI2 Q96SN7 3/20 0.44
ORAI3 Q9BRQ5 3/20 0.44
PCSK9 Q8NBP7 2/20 0.44
CA4 P22748 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2526776 0.98 KMT2A (0.45) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL363448 0.79 TRPV6 (0.46) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL1660275 0.77 TRPV6 (0.44) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL1722636 0.77 PCSK9 (0.45) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL1129435 0.77 TRPV6 (0.44) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL2199544 0.76 CYP1A2 (0.50) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL18550249 0.76 TSHR (0.46) ALDH1A1CYP1A2TSHRMAPK1KMT2A
Benzene SCHEMBL10445518 0.76 ALDH1A1 (0.45) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL117263 0.76 ALDH1A1 (0.45) KDM4EMEN1TRPM2ALDH1A1CYP1A2
SCHEMBL20509988 0.75 KDM4E (0.43) KDM4EMEN1TRPM2ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108342049-B Physical split-phase dynamic polymer and application thereof 厦门天策材料科技有限公司 2023-08-22 CN claimed
CN-114748637-A Phenylboronic acid modified nano-crystal drug stabilizing system and preparation method and application thereof 中国药科大学 2022-07-15 CN claimed
CN-114712520-A Nanocrystalline drug stabilizing system, preparation method, pharmaceutical composition and application 中国药科大学 2022-07-08 CN claimed
CN-112280227-A PVA plasticizer composition and PVA optical film 熊烈祥 2021-01-29 CN claimed
CN-111251500-B Foaming polymer particles with skin dilatancy and preparation method thereof 厦门天策材料科技有限公司 2024-10-22 CN disclosed
CN-114712520-B Nanocrystalline drug stabilization system, preparation method, pharmaceutical composition and application 中国药科大学 2024-02-27 CN disclosed
CN-114748637-B Phenylboronic acid modified nanocrystalline drug stabilization system and preparation method and application thereof 中国药科大学 2023-11-17 CN disclosed
CN-108342049-B Physical split-phase dynamic polymer and application thereof 厦门天策材料科技有限公司 2023-08-22 CN disclosed
CN-111253583-B Dilatant hybrid dynamic polymer and dilatant realization method thereof 厦门天策材料科技有限公司 2023-05-16 CN disclosed
CN-111040204-B Force-induced response dynamic polymer and application thereof 厦门天策材料科技有限公司 2023-01-24 CN disclosed
CN-114748637-A Phenylboronic acid modified nano-crystal drug stabilizing system and preparation method and application thereof 中国药科大学 2022-07-15 CN disclosed
CN-114712520-A Nanocrystalline drug stabilizing system, preparation method, pharmaceutical composition and application 中国药科大学 2022-07-08 CN disclosed
WO-2017061957-A1 COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2017-04-13 WO disclosed
EP-2493907-A2 DERIVATIVES OF URIDINE PHOSPHATE AND THEIR USES IN PROTEIN BINDING ASSAYS Kings College London of Strand (GB) 2012-09-05 EP disclosed
US-7977120-B2 Fluorescent sensors for cellular amines THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2011-07-12 US disclosed
WO-2011051733-A2 COMPOUNDS AND THEIR USES IN PROTEIN BINDING ASSAYS UNIVERSITY OF EAST ANGLIA (GB) 2011-05-05 WO disclosed
US-20090011454-A1 Fluorescent Sensors for Cellular Amines The Curators of the University of Missouri Office of Technology and Special Projects (US) 2009-01-08 US disclosed
EP-1966163-A1 PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA Boehringer Ingelheim International GmbH (DE) 2008-09-10 EP disclosed
WO-2007076247-A1 PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-07-05 WO disclosed
WO-2007016495-A2 FLUORESCENT SENSORS FOR CELLULAR AMINES THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2007-02-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090011454-A1 Fluorescent Sensors for Cellular Amines SLC18A1, TAAR5, MAOA KDM4E 2820/4885MEN1 252/4885TRPM2 595/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.