Bufeniode

Bufeniode

SCHEMBL309865

CC(CCc1ccccc1)NC(C)C(O)c1cc(I)c(O)c(I)c1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 5/20 0.70
CYP2D6 P10635 4/20 0.70
ADRA2A P08913 4/20 0.70
HIF1A Q16665 4/20 0.70
LMNA P02545 3/20 0.70
ADRB2 P07550 3/20 0.70
ADRB1 P08588 3/20 0.70
HTR1A P08908 3/20 0.70
SLC6A2 P23975 3/20 0.70
OPRM1 P35372 3/20 0.70
DRD3 P35462 3/20 0.70
SLC6A3 Q01959 3/20 0.70
CYP1A2 P05177 3/20 0.70
CYP2C19 P33261 3/20 0.70
OPRK1 P41145 2/20 0.70
HTR2B P41595 2/20 0.70
NFKB1 P19838 2/20 0.70
ADRA2B P18089 2/20 0.70
ADRA2C P18825 2/20 0.70
KCNH2 Q12809 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nylidrin SCHEMBL159150 0.82 HIF1A (1.00) ADRA1ACYP2D6ADRA2AHIF1ALMNA
Nylidrin SCHEMBL3701975 0.82 HIF1A (1.00) ADRA1ACYP2D6ADRA2AHIF1ALMNA
Nylidrin SCHEMBL15517085 0.82 HIF1A (1.00) ADRA1ACYP2D6ADRA2AHIF1ALMNA
Nylidrin SCHEMBL364078 0.81 ADRA1A (1.00) ADRA1ACYP2D6ADRA2AHIF1ALMNA
Nylidrin SCHEMBL15512520 0.80 HIF1A (0.95) ADRA1ACYP2D6ADRA2AHIF1ALMNA
SCHEMBL17565768 0.80 SLC6A2 (0.80) ADRA1ACYP2D6ADRA2AHIF1ALMNA
SCHEMBL10777564 0.72 ADRA1A (0.59) ADRA1ACYP2D6ADRA2AHIF1ALMNA
SCHEMBL10526089 0.70 ADRA1A (0.57) ADRA1ACYP2D6ADRA2AHIF1ALMNA
SCHEMBL10523532 0.70 ADRA1A (0.57) ADRA1ACYP2D6ADRA2AHIF1ALMNA
Nylidrin SCHEMBL13724281 0.70 ADRB2 (0.73) ADRA1ACYP2D6ADRA2AHIF1ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119233997-A Tetrahedral antibodies 生物分子控股有限责任公司 2024-12-31 CN claimed
EP-4463485-A2 TETRAHEDRAL ANTIBODIES Biomolecular Holdings LLC (US) 2024-11-20 EP claimed
WO-2023183932-A2 MONOBODIES BINDING TO INTERCELLULAR ADHESION MOLECULE 2 (ICAM-2) NEW YORK UNIVERSITY (US) 2023-09-28 WO claimed
WO-2023137387-A2 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-20 WO claimed
WO-2023137373-A1 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-20 WO claimed
US-20230220116-A1 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-13 US claimed
US-20230220115-A1 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2023-07-13 US claimed
EP-4178615-A1 TETRAHEDRAL ANTIBODIES Biomolecular Holdings LLC (US) 2023-05-17 EP claimed
US-11225490-B2 Prodrugs of secondary amine compounds ALKERMES PHARMA IRELAND LIMITED (IE) 2022-01-18 US claimed
WO-2022011358-A1 TETRAHEDRAL ANTIBODIES BIOMOLECULAR HOLDINGS LLC (US) 2022-01-13 WO claimed
EP-1192129-A2 PHARMACEUTICAL COMPOUNDS NICOX S.A. (FR) 2002-04-03 EP claimed
EP-1169298-A2 PHARMACEUTICAL COMPOUNDS NICOX S.A. (FR) 2002-01-09 EP claimed
US-6302875-B1 Catheters and related devices for forming passageways between blood vessels or other anatomical structures TRANSVASCULAR, INC. 2001-10-16 US claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
WO-2001012584-A2 PHARMACEUTICAL COMPOUNDS NICOX S.A. (FR) 2001-02-22 WO claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000061549-A2 PHARMACEUTICAL COMPOUNDS NICOX S.A. (FR) 2000-10-19 WO claimed
WO-2000061541-A2 PHARMACEUTICAL COMPOUNDS NICOX S.A. (FR) 2000-10-19 WO claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0046270-A1 Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them INTERx RESEARCH CORPORATION (US) 1982-02-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230220115-A1 TETRAHEDRAL ANTIBODIES FCGR3B, FCGR2A, FCGR1A ADRA1A 4669/4885CYP2D6 4821/4885ADRA2A 4717/4885
US-20230220116-A1 TETRAHEDRAL ANTIBODIES FCGR3B, FCGR2A, FCGR1A ADRA1A 4669/4885CYP2D6 4821/4885ADRA2A 4717/4885
US-11225490-B2 Prodrugs of secondary amine compounds HNMT, MAOB, UGT1A1 ADRA1A 328/4885CYP2D6 10/4885ADRA2A 293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.