Water

Water

SCHEMBL175846

O.O=C(O)C(=O)C(=O)O.[NaH]

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.31
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
LDHA P00338 1/20 0.36
LDHB P07195 1/20 0.36
KDM5B Q9UGL1 1/20 0.31
FFAR3 O14843 1/20 0.31
LCK P06239 1/20 0.31
FYN P06241 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL715193 0.95
SCHEMBL6518958 0.95
Water SCHEMBL10863045 0.95 CA1 (0.40) CA1CA2CA9LDHALDHB
Water SCHEMBL27791587 0.90 CA1 (0.36) CA1CA2CA9LDHALDHB
Water SCHEMBL27701356 0.90 CA1 (0.36) CA1CA2CA9LDHALDHB
SCHEMBL1122402 0.89 CA1 (0.44) CA1CA2CA9LDHALDHB
SCHEMBL28953 0.89
Ammonia Solution, Strong SCHEMBL27770412 0.86 LDHA (0.33) CA1CA2CA9LDHALDHB
Water SCHEMBL27781425 0.86 LDHA (0.33) CA1CA2CA9LDHALDHB
Hydrochloric Acid SCHEMBL11010496 0.84 CA1 (0.40) CA1CA2CA9LDHALDHB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2611878-A2 SILICON POLISHING COMPOSITIONS WITH HIGH RATE AND LOW DEFECTIVITY Cabot Microelectronics Corporation (US) 2013-07-10 EP claimed
US-8273142-B2 Silicon polishing compositions with high rate and low defectivity CABOT MICROELECTRONICS CORPORATION (US) 2012-09-25 US claimed
US-20120058642-A1 Silicon polishing compositions with high rate and low defectivity CMC MATERIALS LLC 2012-03-08 US claimed
WO-2012030752-A2 SILICON POLISHING COMPOSITIONS WITH HIGH RATE AND LOW DEFECTIVITY CABOT MICROELECTRONICS CORPORATION (US) 2012-03-08 WO claimed
US-20240191365-A1 METAL COMPOUND BASED CATALYSTS FOR ELECTROSYNTHESIS OF HYDROGEN PEROXIDE AND LINEAR PAIRED ELECTROCHEMICAL VALORIZATION OF BIOMASS-DERIVED FEEDSTOCKS WISCONSIN ALUMNI RESEARCH FOUNDATION 2024-06-13 US disclosed
US-10446852-B2 Fuel-cell system and method of generating energy from crude fuel IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2019-10-15 US disclosed
US-9908819-B1 Printing method for production a ceramic green body WZR ceramic solutions GmbH (DE) 2018-03-06 US disclosed
US-20170263945-A1 FUEL-CELL SYSTEM AND METHOD OF GENERATING ENERGY FROM CRUDE FUEL IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2017-09-14 US disclosed
US-9683123-B2 Silver ink PESOLVE CO., LTD. (KR) 2017-06-20 US disclosed
US-20160168408-A1 SILVER INK PESOLVE CO., LTD. (KR) 2016-06-16 US disclosed
EP-2611878-A2 SILICON POLISHING COMPOSITIONS WITH HIGH RATE AND LOW DEFECTIVITY Cabot Microelectronics Corporation (US) 2013-07-10 EP disclosed
US-8309552-B2 Immunomodulating heterocyclic compounds MEDIGENE AG (DE) 2012-11-13 US disclosed
EP-1603917-B1 IMMUNOMODULATING HETEROCYCLIC COMPOUNDS MEDIGENE LTD (GB) 2010-11-24 EP disclosed
US-20090312334-A1 Immunomodulating Heterocyclic Compounds MEDIGENE LIMITED (GB) 2009-12-17 US disclosed
US-7598247-B2 Immunomodulating heterocyclic compounds MEDIGENE LIMITED (GB) 2009-10-06 US disclosed
US-20080045527-A1 Immunomodulating Heterocyclic Compounds MEDIGENE LIMITED (GB) 2008-02-21 US disclosed
US-7276505-B2 Immunomodulating heterocyclic compounds MEDIGENE LIMITED (GB) 2007-10-02 US disclosed
US-20070021428-A1 Immunomodulating heterocyclic compounds AVIDEX LIMITED (GB) 2007-01-25 US disclosed
EP-1603917-A1 IMMUNOMODULATING HETEROCYCLIC COMPOUNDS Avidex Limited (GB) 2005-12-14 EP disclosed
WO-2004081011-A1 IMMUNOMODULATING HETEROCYCLIC COMPOUNDS AVIDEX LIMITED (GB) 2004-09-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312334-A1 Immunomodulating Heterocyclic Compounds CD40, CD40LG, NGFR ACHE 3369/4885CA1 2084/4885CA2 2508/4885
US-20160168408-A1 SILVER INK TP53, MKI67, NRAS ACHE 2042/4885CA1 3304/4885CA2 3267/4885
US-20080045527-A1 Immunomodulating Heterocyclic Compounds CD40, CD40LG, NGFR ACHE 3369/4885CA1 2084/4885CA2 2508/4885
US-20070021428-A1 Immunomodulating heterocyclic compounds CD40, CD40LG, NGFR ACHE 3264/4885CA1 1652/4885CA2 2376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.