Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 3/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908424 | 0.88 | BTK (0.43) | CDC25BKEAP1NFE2L2CRHBPCRHR2 | |
| SCHEMBL19923221 | 0.81 | HSD17B10 (0.59) | NR4A1NR4A2NR4A3MYCHSD17B10 | |
| SCHEMBL22684102 | 0.78 | MYC (0.45) | KEAP1MYCHSD17B10MMP2IDO1 | |
| SCHEMBL27795732 | 0.75 | ALDH1A1 (0.55) | CDC25BNR4A1NR4A2NR4A3MYC | |
| SCHEMBL121804 | 0.74 | HNF4A (0.63) | CDC25BMYCHSD17B10ALDH1A1KMT2A | |
| SCHEMBL629199 | 0.74 | CDC25B (0.54) | CDC25BNR4A1NR4A2NR4A3KEAP1 | |
| SCHEMBL689824 | 0.74 | CDC25B (0.64) | CDC25BNR4A1NR4A2NR4A3NSD2 | |
| SCHEMBL602307 | 0.74 | MMP2 (0.61) | CDC25BNR4A1NR4A2NR4A3KEAP1 | |
| SCHEMBL31227767 | 0.74 | MMP2 (0.61) | CDC25BNR4A1NR4A2NR4A3KEAP1 | |
| SCHEMBL29549315 | 0.74 | CDC25B (0.64) | CDC25BNR4A1NR4A2NR4A3NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |