Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | PTGFR | P43088 | 3/20 | 0.35 |
| ▸ | RORC | P51449 | 8/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17613380 | 0.82 | PTGER1 (0.37) | TTRPTGFRRORCEP300CREBBP | |
| SCHEMBL17599305 | 0.79 | ACLY (0.55) | ACLYPTK2BSMN1; SMN2 | |
| SCHEMBL17599385 | 0.74 | TSHR (0.47) | TTRACLYPTK2BSMN1; SMN2 | |
| SCHEMBL17599320 | 0.68 | SMN1; SMN2 (0.54) | ACLYPTK2BSMN1; SMN2 | |
| SCHEMBL17613384 | 0.67 | NR1H4 (0.45) | PTK2BSMN1; SMN2 | |
| SCHEMBL17599341 | 0.67 | FABP4 (0.43) | PTGFRACLYPTK2BSMN1; SMN2 | |
| SCHEMBL17599333 | 0.66 | PTK2B (0.52) | ACLYPTK2BSMN1; SMN2 | |
| SCHEMBL17613344 | 0.66 | FABP4 (0.41) | PTGER4 | |
| SCHEMBL17599338 | 0.66 | FABP4 (0.42) | ACLYPTK2BSMN1; SMN2 | |
| SCHEMBL17613338 | 0.66 | NR1H4 (0.41) | PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |