Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.47 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599375 | 0.79 | ACLY (0.49) | ACLYFABP4PTK2BSMN1; SMN2KDM4E | |
| SCHEMBL17599385 | 0.71 | TSHR (0.47) | ACLYFABP4PTK2BSMN1; SMN2MAPT | |
| SCHEMBL17599370 | 0.69 | ALDH1A1 (0.53) | ACLYFABP4PTK2BSMN1; SMN2KDM4E | |
| SCHEMBL17613353 | 0.69 | FABP4 (0.38) | ACLYFABP4PTK2BSMN1; SMN2BRD4 | |
| SCHEMBL17599320 | 0.69 | SMN1; SMN2 (0.54) | ACLYFABP4PTK2BSMN1; SMN2KDM4E | |
| SCHEMBL17599305 | 0.67 | ACLY (0.55) | ACLYFABP4PTK2BSMN1; SMN2MCL1 | |
| SCHEMBL17599355 | 0.67 | PTK2B (0.43) | ACLYFABP4PTK2BSMN1; SMN2RAD52 | |
| SCHEMBL17599392 | 0.66 | CCKBR (0.47) | ACLYFABP4PTK2BSMN1; SMN2NPC1 | |
| SCHEMBL17599333 | 0.65 | PTK2B (0.52) | ACLYFABP4PTK2BSMN1; SMN2MEN1 | |
| SCHEMBL17599338 | 0.65 | FABP4 (0.42) | ACLYFABP4PTK2BSMN1; SMN2RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998294-A1 | Naphthyl sulfonamide phenyl derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |