Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ITK | Q08881 | 6/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632020 | 0.93 | MAPT (0.46) | WNT3AMAPTITKMAOAMAOB | |
| SCHEMBL17632007 | 0.89 | LIPG (0.41) | ABL1MAP4K1LMNA | |
| SCHEMBL17632490 | 0.85 | MAPT (0.43) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL17631942 | 0.84 | MAP4K1 (0.34) | ABL1MAPTITKMAP4K1 | |
| SCHEMBL17632035 | 0.84 | ABL1 (0.45) | ABL1LCKMAP4K1 | |
| SCHEMBL17632611 | 0.82 | RAB9A (0.37) | MAPTLMNAKMT2A | |
| SCHEMBL17632567 | 0.81 | BRD4 (0.47) | MAP4K1LMNA | |
| SCHEMBL17631984 | 0.81 | DYRK1A (0.33) | MAPTITKMAP4K1TP53 | |
| SCHEMBL17631887 | 0.81 | USP30 (0.44) | ABL1MAPTMAP4K1 | |
| SCHEMBL17632621 | 0.80 | ALDH1A1 (0.47) | MAPTMAOBLMNATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |