SCHEMBL1764085

SCHEMBL1764085

COc1ccc(-c2cc(=O)c3c(O)c(OC)c(OC)c(OC)c3o2)cc1O

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.84
CYP3A4 P08684 3/20 0.84
MAPT P10636 3/20 0.84
MAPK1 P28482 3/20 0.84
USP2 O75604 1/20 0.84
LMNA P02545 1/20 0.84
ELANE P08246 1/20 0.84
PPARG P37231 2/20 0.73
KDM4E B2RXH2 2/20 0.72
MEN1 O00255 2/20 0.72
KMT2A Q03164 2/20 0.72
POLB P06746 1/20 0.72
GAA P10253 1/20 0.72
RECQL P46063 1/20 0.72
L3MBTL1 Q9Y468 1/20 0.72
AURKA O14965 1/20 0.71
CYP1A1 P04798 1/20 0.71
KDR P35968 1/20 0.71
FLT3 P36888 1/20 0.71
CYP1B1 Q16678 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12469965 0.93 ALDH1A1 (0.72) ALDH1A1CYP3A4MAPTMAPK1USP2
SCHEMBL30082749 0.93 ALDH1A1 (0.79) ALDH1A1CYP3A4MAPTMAPK1USP2
SCHEMBL1764091 0.93 ALDH1A1 (0.79) ALDH1A1CYP3A4MAPTMAPK1USP2
5-Demethylnobiletin SCHEMBL31237479 0.91 ALDH1A1 (1.00) ALDH1A1CYP3A4MAPTMAPK1USP2
5-Demethylnobiletin SCHEMBL1764120 0.91 ALDH1A1 (1.00) ALDH1A1CYP3A4MAPTMAPK1USP2
5-Demethylnobiletin SCHEMBL29606981 0.91 ALDH1A1 (1.00) ALDH1A1CYP3A4MAPTMAPK1USP2
SCHEMBL10997058 0.90 ALDH1A1 (0.88) ALDH1A1CYP3A4MAPTMAPK1USP2
Sideritiflavone SCHEMBL29973995 0.90 PPARG (0.77) ALDH1A1CYP3A4MAPTMAPK1USP2
SCHEMBL16894632 0.86 ACHE (0.76) ALDH1A1CYP3A4MAPTMAPK1USP2
SCHEMBL29928538 0.86 ALDH1A1 (0.88) ALDH1A1CYP3A4MAPTMAPK1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 EP claimed
WO-2024220449-A9 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2025-04-03 WO claimed
US-20250011393-A1 FLAVONOID-COLLAGEN CROSSLINKED ANTIOXIDANT HYDROGEL NORTH CAROLINA STATE UNIVERSITY 2025-01-09 US claimed
WO-2024220449-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) 2024-10-24 WO claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
WO-2023064318-A1 BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE Natural Extraction Systems, LLC (US) 2023-04-20 WO claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 US claimed
WO-2022182523-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 WO claimed
WO-2021158575-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2021-08-12 WO claimed
EP-2010194-A2 HYDROXYLATED POLYMETHOXYFLAVONE COMPOSITIONS Rutgers, The State University of New Jersey (US) 2009-01-07 EP claimed
US-20070275106-A1 Hydroxylated polymethoxyflavone compositions WELLGEN, INC. 2007-11-29 US claimed
WO-2007109071-A2 HYDROXYLATED POLYMETHOXYFLAVONE COMPOSITIONS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2007-09-27 WO claimed
US-20070191330-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases PROTEOTECH, INC. 2007-08-16 US claimed
EP-1808169-A2 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases Proteotech Inc. (US) 2007-07-18 EP claimed
US-20040152760-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases PROTAMED, INC. 2004-08-05 US claimed
JP-2003532634-A 2003-11-05 JP claimed
EP-1244435-A2 POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND $g(a)-SYNUCLEIN FIBRIL DISEASES Proteotech Inc. (US) 2002-10-02 EP claimed
US-20010047032-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases PROTAMED, INC. 2001-11-29 US claimed
WO-2001049281-A2 POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND α-SYNUCLEIN FIBRIL DISEASES PROTEOTECH, INC. (US) 2001-07-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES FABP2, FABP4, GUSB ALDH1A1 2722/4885CYP3A4 3571/4885MAPT 3926/4885
US-20070191330-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases SNCA, PARK7, HTT ALDH1A1 1297/4885CYP3A4 3677/4885MAPT 4/4885
US-20010047032-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases SNCA, PARK7, HTT ALDH1A1 1370/4885CYP3A4 3527/4885MAPT 4/4885
US-20070275106-A1 Hydroxylated polymethoxyflavone compositions PLIN5, FANCF, COXFA4 ALDH1A1 1794/4885CYP3A4 390/4885MAPT 4329/4885
US-20040152760-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases SNCA, PARK7, HTT ALDH1A1 1370/4885CYP3A4 3527/4885MAPT 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.