SCHEMBL1765839

SCHEMBL1765839

CN1c2nc(N)[nH]c(=O)c2NC1S

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 5/20 0.41
NOS1 P29475 6/20 0.38
USP2 O75604 1/20 0.38
CASP7 P55210 1/20 0.38
HSD17B10 Q99714 1/20 0.38
PAH P00439 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GLA P06280 1/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
BLM P54132 1/20 0.37
PMP22 Q01453 1/20 0.37
KMT2A Q03164 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
NOS3 P29474 1/20 0.36
NOS2 P35228 1/20 0.36
PNP P00491 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8798202 0.81 HPRT1 (0.49) HPRT1NOS1USP2CASP7HSD17B10
SCHEMBL2982031 0.81 HPRT1 (0.53) HPRT1NOS1USP2CASP7HSD17B10
SCHEMBL19464457 0.68 HPRT1 (0.47) HPRT1MAPTPNP
SCHEMBL10870536 0.68 HPRT1 (0.40) HPRT1NOS1USP2CASP7HSD17B10
SCHEMBL2787048 0.67 HPRT1 (0.50) HPRT1NOS1USP2CASP7HSD17B10
SCHEMBL10871616 0.66 TK1 (0.46) HPRT1NOS1NOS3NOS2PNP
SCHEMBL10873210 0.64 HPRT1 (0.61) HPRT1NOS1PNP
SCHEMBL10872985 0.64 HPRT1 (0.46) HPRT1NOS1PNP
SCHEMBL9544019 0.62 PNP (0.36) HSD17B10KDM4EALDH1A1GLAPMP22
SCHEMBL9545264 0.62 XDH (0.35) HSD17B10KDM4EALDH1A1GLAPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190317040-A1 DEVICES AND METHODS FOR TARGET MOLECULE CHARACTERIZATION ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-10-17 US disclosed
US-10442771-B2 Trans-base tunnel reader for sequencing ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-10-15 US disclosed
US-10330632-B2 Devices and methods for target molecule characterization ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-06-25 US disclosed
US-20170204066-A1 NANOPORE BASED SEQUENCER ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-07-20 US disclosed
US-9593372-B2 Nanopore based sequencer ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2017-03-14 US disclosed
US-20170003245-A1 DEVICES AND METHODS FOR TARGET MOLECULE CHARACTERIZATION ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-01-05 US disclosed
US-9395352-B2 Devices and methods for target molecule characterization ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2016-07-19 US disclosed
US-20150211059-A1 TRANS-BASE TUNNEL READER FOR SEQUENCING ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2015-07-30 US disclosed
US-8968540-B2 Trans-base tunnel reader for sequencing ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-03-03 US disclosed
US-8961757-B2 Nanopore and carbon nanotube based DNA sequencer ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-02-24 US disclosed
US-20130186757-A1 Nanopore and Carbon Nanotube Based Dna Sequencer and A Serial Recognition Elements ARIZONA BOARD OF REGENTS (US) 2013-07-25 US disclosed
US-20110168562-A1 Nanopore and Carbon Nanotube Based DNA Sequencer ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY 2011-07-14 US disclosed
US-20110120868-A1 Nanopore and Carbon Nanotube Based DNA Sequencer and a Serial Recognition Sequencer ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2011-05-26 US disclosed
WO-2010042514-A1 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER AND A SERIAL RECOGNITION ELEMENTS ARIZONA BOARD OF REGENTS (US) 2010-04-15 WO disclosed
US-20100084276-A1 Devices and Methods for Target Molecule Characterization NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-08 US disclosed
WO-2009117522-A2 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER AND A SERIAL RECOGNITION SEQUENCER REINHART, KEVIN (US) 2009-09-24 WO disclosed
WO-2009117517-A2 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2009-09-24 WO disclosed
WO-2008124706-A9 DEVICES AND METHODS FOR TARGET MOLECULE CHARACTERIZATION UNIV ARIZONA STATE (US) 2009-05-28 WO disclosed
WO-2008124706-A2 DEVICES AND METHODS FOR TARGET MOLECULE CHARACTERIZATION ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2008-10-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170204066-A1 NANOPORE BASED SEQUENCER DNMT3A, DNTT, TELO2 HPRT1 1664/4885NOS1 2203/4885USP2 2908/4885
US-10442771-B2 Trans-base tunnel reader for sequencing DNTT, TRDMT1, TELO2 HPRT1 317/4885NOS1 2407/4885USP2 4350/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.