Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69653 | 0.87 | MAPT (0.64) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17276045 | 0.85 | MAPT (0.55) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18157886 | 0.80 | KDM4E (0.46) | MAPTCYP1A2CYP3A4KDM4ETSHR | |
| SCHEMBL6180691 | 0.80 | ALDH1A1 (0.50) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29509427 | 0.79 | KDM4E (0.68) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1829272 | 0.79 | MAPT (0.57) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1500410 | 0.79 | KDM4E (0.68) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL20963454 | 0.79 | MAPT (0.50) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28409913 | 0.79 | MAPT (0.50) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2162898 | 0.79 | P2RX7 (0.64) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212642-B1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORGAMMAT | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |
| CN-108064224-A | Amide-substituted thiazoles as modulators of Ror gamma t | 詹森药业有限公司 | 2018-05-22 | — | — | CN | disclosed |
| US-9845319-B2 | Amide substituted thiazoles as modulators of RORyt | Janssen Pharmaceutiuca NV (BE) | 2017-12-19 | — | — | US | disclosed |
| US-9845319-B2 | Amide substituted thiazoles as modulators of RORyt | Janssen Pharmaceutiuca NV (BE) | 2017-12-19 | — | — | US | disclosed |
| US-9845319-B2 | Amide substituted thiazoles as modulators of RORyt | Janssen Pharmaceutiuca NV (BE) | 2017-12-19 | — | — | US | disclosed |
| US-20160122335-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122335-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160122335-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (US) | 2016-05-05 | — | — | US | disclosed |
| US-20150152042-A1 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY | ACADIA PHARMACEUTICALS INC. | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122335-A1 | AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyt | RORC, RORA, RORB | MAPT 1992/4885CYP1A2 297/4885SMN1; SMN2 4167/4885 |
| US-20150152042-A1 | SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY | SLC6A4, HTR4, GPR34 | MAPT 183/4885CYP1A2 1625/4885SMN1; SMN2 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.