Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018111 | 0.86 | PAX8 (0.55) | NOTUMTSHRSMN1; SMN2NPC1GAA | |
| SCHEMBL18767131 | 0.84 | NOTUM (0.45) | NOTUMALDH1A1TSHRKDM4EHSD17B10 | |
| SCHEMBL23407754 | 0.83 | RAB9A (0.54) | NOTUMALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL846595 | 0.83 | PAX8 (0.51) | NOTUMALDH1A1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL12268059 | 0.82 | PAX8 (0.47) | NOTUMALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL2685272 | 0.82 | BRD4 (0.48) | NOTUMALDH1A1TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL17122860 | 0.81 | PAX8 (0.46) | NOTUMALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4838149 | 0.80 | NOTUM (0.49) | NOTUMALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL64028 | 0.80 | NOTUM (0.49) | NOTUMALDH1A1TSHRKDM4EHPGD | |
| SCHEMBL3364970 | 0.80 | PAX8 (0.50) | NOTUMTSHRSMN1; SMN2GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230065629-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2023-03-02 | — | — | US | disclosed |
| US-11208400-B2 | Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof | BAYER AKTIENGESELLSCHAFT (DE) | 2021-12-28 | — | — | US | disclosed |
| US-11208400-B2 | Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof | BAYER AKTIENGESELLSCHAFT (DE) | 2021-12-28 | — | — | US | disclosed |
| EP-3526212-B1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AG (DE) | 2021-12-22 | — | — | EP | disclosed |
| EP-3526212-B1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AG (DE) | 2021-12-22 | — | — | EP | disclosed |
| US-20200055842-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2020-02-20 | — | — | US | disclosed |
| US-20200055842-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2020-02-20 | — | — | US | disclosed |
| CN-110191884-A | Substituted 6- (1H-pyrazol-1-yl) pyrimidine-4-amine derivatives and uses thereof | 拜耳公司 | 2019-08-30 | — | — | CN | disclosed |
| EP-3526212-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | Bayer Aktiengesellschaft (DE) | 2019-08-21 | — | — | EP | disclosed |
| US-10350315-B2 | Quinoline-3-carboxamide compounds and their use in diagnosis | Westfaelische Wihelms-Universitaet Muenster (DE) | 2019-07-16 | — | — | US | disclosed |
| US-10350315-B2 | Quinoline-3-carboxamide compounds and their use in diagnosis | Westfaelische Wihelms-Universitaet Muenster (DE) | 2019-07-16 | — | — | US | disclosed |
| WO-2018069222-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-04-19 | — | — | WO | disclosed |
| WO-2018069222-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2018-04-19 | — | — | WO | disclosed |
| US-20170333577-A1 | QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN DIAGNOSIS | Westfälische Wilhelms-Universität Münster (DE) | 2017-11-23 | — | — | US | disclosed |
| US-20170333577-A1 | QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN DIAGNOSIS | Westfälische Wilhelms-Universität Münster (DE) | 2017-11-23 | — | — | US | disclosed |
| US-20170333577-A1 | QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN DIAGNOSIS | Westfälische Wilhelms-Universität Münster (DE) | 2017-11-23 | — | — | US | disclosed |
| EP-3212239-A1 | QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN DIAGNOSIS | Westfälische Wilhelms-Universität Münster (DE) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016067238-A1 | QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN DIAGNOSIS | WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (DE) | 2016-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350315-B2 | Quinoline-3-carboxamide compounds and their use in diagnosis | S100A9, S100A4, S100A10 | NOTUM 3171/4885ALDH1A1 3371/4885TSHR 4679/4885 |
| US-11208400-B2 | Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof | REN, ATP6V1B1, GLS | NOTUM 1278/4885ALDH1A1 211/4885TSHR 4285/4885 |
| US-20170333577-A1 | QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN DIAGNOSIS | S100A9, S100A4, S100A10 | NOTUM 3171/4885ALDH1A1 3371/4885TSHR 4679/4885 |
| US-20200055842-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | REN, ATP6V1B1, GLS | NOTUM 1278/4885ALDH1A1 211/4885TSHR 4285/4885 |
| US-20230065629-A1 | SUBSTITUTED 6-(1H-PYRAZOL-1-YL)PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | REN, ATP6V1B1, GLS | NOTUM 1278/4885ALDH1A1 211/4885TSHR 4285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.