Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11874540 | 0.83 | HSD17B10 (0.74) | HSD17B10TSHRALDH1A1CYP1A2NLRP3 | |
| SCHEMBL2742152 | 0.80 | ALDH1A1 (0.57) | HSD17B10TSHRALDH1A1CYP1A2NLRP3 | |
| SCHEMBL17737203 | 0.78 | SIRT5 (0.61) | HSD17B10TSHRSIRT5HDAC4MAPT | |
| Benzene SCHEMBL7281101 | 0.77 | ALDH1A1 (0.54) | HSD17B10TSHRALDH1A1CYP1A2NLRP3 | |
| SCHEMBL2384797 | 0.76 | ALDH1A1 (0.65) | ALDH1A1CYP1A2NLRP3PKMKMT2A | |
| SCHEMBL26456643 | 0.74 | MGLL (0.54) | HSD17B10TSHRHDAC4 | |
| SCHEMBL21666142 | 0.73 | SIRT2 (0.49) | HSD17B10TSHRALDH1A1SIRT5HDAC4 | |
| SCHEMBL20152024 | 0.73 | ALDH1A1 (0.61) | HSD17B10ALDH1A1CYP1A2NLRP3PKM | |
| SCHEMBL23729020 | 0.73 | LTA4H (0.49) | HSD17B10KMT2AMEN1NPC1RAB9A | |
| SCHEMBL15317942 | 0.73 | LMNA (0.46) | HSD17B10TSHRALDH1A1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160130246-A1 | THIOUREA COMPOUNDS AND THEIR USE AS INHIBITORS OF SIRT2 OR SIRT5 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130246-A1 | THIOUREA COMPOUNDS AND THEIR USE AS INHIBITORS OF SIRT2 OR SIRT5 | SIRT2, SIRT3, SIRT1 | HSD17B10 1237/4885TSHR 373/4885ALDH1A1 1921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.