SCHEMBL1781166

SCHEMBL1781166

[c]1ccc(-c2c[nH]c3ccccc23)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 3/20 0.62
NR4A2 P43354 1/20 0.62
MAPK1 P28482 1/20 0.62
HSD17B10 Q99714 1/20 0.62
TDO2 P48775 7/20 0.49
SIRT2 Q8IXJ6 2/20 0.49
PRKD3 O94806 1/20 0.49
CCNB2 O95067 1/20 0.49
CCNE2 O96020 1/20 0.49
ABL1 P00519 1/20 0.49
PRKCG P05129 1/20 0.49
PRKCB P05771 1/20 0.49
CDK1 P06493 1/20 0.49
PIM1 P11309 1/20 0.49
CDK4 P11802 1/20 0.49
CCNB1 P14635 1/20 0.49
PRKCA P17252 1/20 0.49
PRKACA P17612 1/20 0.49
PRKACG P22612 1/20 0.49
PRKACB P22694 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28377762 0.86 NR4A2 (0.81) IMPDH2NR4A2MAPK1HSD17B10TDO2
SCHEMBL28416622 0.84 NR4A2 (0.78) IMPDH2NR4A2MAPK1HSD17B10TDO2
3-Phenylindole SCHEMBL29609072 0.84 IMPDH2 (0.71) IMPDH2NR4A2MAPK1HSD17B10TDO2
3-Phenylindole SCHEMBL84056 0.84 IMPDH2 (0.71) IMPDH2NR4A2MAPK1HSD17B10TDO2
SCHEMBL3132122 0.80 IMPDH2 (0.53) IMPDH2NR4A2MAPK1HSD17B10TDO2
SCHEMBL5552863 0.80 IMPDH2 (0.49) IMPDH2NR4A2MAPK1HSD17B10TDO2
SCHEMBL28788050 0.80 ALOX5 (0.47) IMPDH2NR4A2MAPK1HSD17B10TDO2
SCHEMBL1202543 0.79 IMPDH2 (0.63) IMPDH2NR4A2MAPK1HSD17B10SIRT2
SCHEMBL699524 0.78 IMPDH2 (0.46) IMPDH2NR4A2MAPK1HSD17B10PRKD3
SCHEMBL19991846 0.78 IMPDH2 (0.46) IMPDH2NR4A2MAPK1HSD17B10PRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113631548-B Serotonin 5-HT2B inhibiting compounds 硕腾服务有限责任公司 2023-06-06 CN claimed
CN-114361341-A Laminated image pickup device and image pickup module 索尼公司 2022-04-15 CN claimed
CN-107534050-B Image sensor, laminated image pickup device, and image pickup module 索尼公司 2021-12-14 CN claimed
CN-113631548-A Serotonin 5-HT2B inhibiting compounds 硕腾服务有限责任公司 2021-11-09 CN claimed
CN-112670425-A Organic light emitting device 三星显示有限公司 2021-04-16 CN claimed
US-20200274077-A1 PHOTOELECTRIC CONVERSION ELEMENT AND IMAGING APPARATUS SONY CORPORATION (JP) 2020-08-27 US claimed
CN-111316459-A Photoelectric conversion element and imaging device 索尼公司 2020-06-19 CN claimed
US-10566548-B2 Image sensor, stacked imaging device and imaging module SONY CORPORATION (JP) 2020-02-18 US claimed
EP-3300114-B1 IMAGING ELEMENT, MULTILAYER IMAGING ELEMENT AND IMAGING DEVICE SONY CORP (JP) 2020-01-08 EP claimed
US-20180114926-A1 IMAGE SENSOR, STACKED IMAGING DEVICE AND IMAGING MODULE SONY CORPORATION (JP) 2018-04-26 US claimed
WO-2008142720-A2 QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS DAC SRL (IT) 2008-11-27 WO claimed
CN-101142185-A Indoles useful in the treatment of inflammation BIOLIPOX AB (SE) 2008-03-12 CN claimed
CN-101006054-A Indoles useful in the treatment of inflammation BIOLIPOX AB (SE) 2007-07-25 CN claimed
CN-1791596-A Anti-cancer medicaments DECIPHERA PHARMACEUTICALS LLC (US) 2006-06-21 CN claimed
US-6699862-B1 ANTITUMOR PFIZER INC. 2004-03-02 US claimed
EP-0770079-B1 HETEROBICYCLIC DERIVATIVES FUJISAWA PHARMACEUTICAL CO (JP) 2003-02-12 EP claimed
US-20020107251-A1 Heterobicyclic derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-08-08 US claimed
US-6426345-B1 PHOSPHODIESTERASE INHIBITORS; ANTIINFLAMMATORY AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-07-30 US claimed
EP-0770079-A1 HETEROBICYCLIC DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-02 EP claimed
WO-1996001825-A1 HETEROBICYCLIC DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-01-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107251-A1 Heterobicyclic derivatives ARSA, ARRB1, SULT2A1 IMPDH2 3948/4885NR4A2 777/4885MAPK1 2643/4885
US-20200274077-A1 PHOTOELECTRIC CONVERSION ELEMENT AND IMAGING APPARATUS PPOX, JUP, L1CAM IMPDH2 3242/4885NR4A2 1352/4885MAPK1 2064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.